Linked Life Data

17454231

Source:http://linkedlifedata.com/resource/pubmed/id/17454231

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2007-4-24
pubmed:abstractText
The purpose of this paper is to determine if a relationship exists between APOE alleles and nonsyndromic, sensorineural hearing loss (SNHL) in adults. APOE genotype was determined on DNA obtained from a sample of 89 subjects with nonsyndromic, adult onset SNHL. Median age was 64 years old, and 51 (57%) were males. Allele frequencies in the study population were compared to those in the general population. Subjects were divided into two groups, one by severity of hearing loss and another by severity of impairment of word recognition. Each group was stratified by severity, and allele frequencies were compared to the general population. The study found that the APOE allele epsilon 4 was less prevalent in the study population with SNHL than in the general population. No relationship was found between the epsilon 4 allele and severity of hearing loss or severity of impairment of word recognition. The study revealed that the APOE epsilon 4 allele was under-represented in the study sample as compared to the general population. Future studies associating the epsilon 4 allele with SNHL need to be population-based, longitudinal, or done in younger subjects.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
1499-2027
pubmed:author
pubmed:issnType
Print
pubmed:volume
46
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
183-6
pubmed:dateRevised
2007-12-3
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Apolipoprotein E alleles and sensorineural hearing loss.
pubmed:affiliation
Department of Surgery (Division of Speech Pathology & Audiology), Duke University Medical Center, Durham, NC 27710, USA.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural