Source:http://linkedlifedata.com/resource/pubmed/id/17453999
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
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pubmed:dateCreated |
2007-4-24
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pubmed:databankReference | |
pubmed:abstractText |
A novel splice variant of human AP3B2, named AP3B2_v2, was isolated through the large-scale sequencing analysis of a human fetal brain cDNA library. The AP3B2_v2 cDNA is 1171 bp in length. Sequence analysis revealed AP3B2_v2 missed 22 exons that existed in AP3B2_v1, leading to a different putative protein. The deduced proteins were 145 amino acids (designated as AP3B2_v2) and 1082 amino acids (AP3B2_v1) in length, sharing the C-terminal 145 amino acids. RT-PCR analysis showed that human AP3B2_v2 were expressed in several human adult tissues analyzed. The expression levels of AP3B2_v2 were relatively high in brain and testis. In contrast, low levels of expression were detected in kidney, pancreas, spleen, thymus, prostate, ovary and small intestine.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1042-5179
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
18
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
165-8
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pubmed:meshHeading |
pubmed-meshheading:17453999-Adaptor Protein Complex 3,
pubmed-meshheading:17453999-Adaptor Protein Complex beta Subunits,
pubmed-meshheading:17453999-Alternative Splicing,
pubmed-meshheading:17453999-Amino Acid Sequence,
pubmed-meshheading:17453999-Base Sequence,
pubmed-meshheading:17453999-Brain,
pubmed-meshheading:17453999-Fetus,
pubmed-meshheading:17453999-Gene Expression,
pubmed-meshheading:17453999-Gene Library,
pubmed-meshheading:17453999-Humans,
pubmed-meshheading:17453999-Molecular Sequence Data,
pubmed-meshheading:17453999-Organ Specificity,
pubmed-meshheading:17453999-Reverse Transcriptase Polymerase Chain Reaction
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pubmed:year |
2007
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pubmed:articleTitle |
Characterization of AP3B2_v2, a novel splice variant of human AP3B2.
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pubmed:affiliation |
State Key Laboratory of Genetic Engineering, School of Life Sciences, Institute of Genetics, Fudan University, Shanghai, 200433, People's Republic of China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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