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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2007-4-24
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pubmed:abstractText |
The immunoreactivity of epidermal growth factor receptor (EGFR) ezrin, hepatocyte growth factor receptor (HGF), and c-Met was studied in 60 uveal melanomas and was correlated with clinicopathologic parameters. Metastases were diagnosed in the patients with uveal melanoma between 5 years and 8 years (median, 6.5 years) after enucleation. Using Kaplan-Meier statistical analysis, we found a significant association between high c-Met expression and death due to uveal melanoma (p < 0.03). EGFR was expressed in 18 of 60 (30%) tumors; ezrin was expressed in 30 of 60 (50%) tumors. Tumors with liver metastasis (n = 6) showed higher expression of c-Met (p = 0.0009) compared with the tumors with no extension/extrascleral extension without liver metastasis (groups A-45 and B-9). HGF was negative in all the six tumors that had liver metastasis. Further studies are required to understand the possible mechanism of ligand-independent c-Met activation in patients with uveal melanoma.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0271-3683
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
32
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
281-90
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:17453948-Adolescent,
pubmed-meshheading:17453948-Adult,
pubmed-meshheading:17453948-Aged,
pubmed-meshheading:17453948-Child,
pubmed-meshheading:17453948-Cytoskeletal Proteins,
pubmed-meshheading:17453948-Epidermal Growth Factor,
pubmed-meshheading:17453948-Female,
pubmed-meshheading:17453948-Hepatocyte Growth Factor,
pubmed-meshheading:17453948-Humans,
pubmed-meshheading:17453948-Immunoenzyme Techniques,
pubmed-meshheading:17453948-Liver Neoplasms,
pubmed-meshheading:17453948-Lymphocytes, Tumor-Infiltrating,
pubmed-meshheading:17453948-Male,
pubmed-meshheading:17453948-Melanoma,
pubmed-meshheading:17453948-Middle Aged,
pubmed-meshheading:17453948-Proto-Oncogene Proteins c-met,
pubmed-meshheading:17453948-Survival Rate,
pubmed-meshheading:17453948-Tumor Markers, Biological,
pubmed-meshheading:17453948-Uveal Neoplasms
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pubmed:year |
2007
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pubmed:articleTitle |
Expression of epidermal growth factor receptor, ezrin, hepatocyte growth factor, and c-Met in uveal melanoma: an immunohistochemical study.
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pubmed:affiliation |
Department of Ocular Pathology, Medical and Vision Research Foundation, Sankara Nethralaya, Chennai, India.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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