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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
2007-6-20
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pubmed:abstractText |
Dutch-belted and New Zealand White rabbits were passively immunized with AVP-21D9, a human monoclonal antibody to protective antigen (PA), at the time of Bacillus anthracis spore challenge using either nasal instillation or aerosol challenge techniques. AVP-21D9 (10 mg/kg) completely protected both rabbit strains against lethal infection with Bacillus anthracis Ames spores, regardless of the inoculation method. Further, all but one of the passively immunized animals (23/24) were completely resistant to rechallenge with spores by either respiratory challenge method at 5 weeks after primary challenge. Analysis of the sera at 5 weeks after primary challenge showed that residual human anti-PA levels decreased by 85 to 95%, but low titers of rabbit-specific anti-PA titers were also measured. Both sources of anti-PA could have contributed to protection from rechallenge. In a subsequent study, bacteriological and histopathology analyses revealed that B. anthracis disseminated to the bloodstream in some naïve animals as early as 24 h postchallenge and increased in frequency with time. AVP-21D9 significantly reduced the dissemination of the bacteria to the bloodstream and to various organs following infection. Examination of tissue sections from infected control animals, stained with hematoxylin-eosin and the Gram stain, showed edema and/or hemorrhage in the lungs and the presence of bacteria in mediastinal lymph nodes, with necrosis and inflammation. Tissue sections from infected rabbits dosed with AVP-21D9 appeared comparable to corresponding tissues from uninfected animals despite lethal challenge with B. anthracis Ames spores. Concomitant treatment with AVP-21D9 at the time of challenge conferred complete protection in the rabbit inhalation anthrax model. Early treatment increased the efficacy progressively and in a dose-dependent manner. Thus, AVP-21D9 could offer an adjunct or alternative clinical treatment regimen against inhalation anthrax.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/17452469-10085028,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17452469-11353060,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17452469-11535328,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17452469-11854261,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17452469-12396928,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17452469-12819066,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17452469-12867985,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17452469-12875989,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17452469-15671576,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17452469-15925272,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17452469-15935874,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17452469-16141341,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17452469-16299324,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17452469-16368995,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17452469-16369003,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17452469-16417950,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17452469-16428748,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17452469-16785422,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17452469-16840255,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/17452469-16988266,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17452469-1730501,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17452469-1903769,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17452469-3148815,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/17452469-8460135,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17452469-9822127
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0019-9567
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pubmed:author |
pubmed-author:BazeWallace BWB,
pubmed-author:BushKathrynK,
pubmed-author:ChatuevBagram MBM,
pubmed-author:ChopraAshok KAK,
pubmed-author:ComerJason EJE,
pubmed-author:HardcastleJasonJ,
pubmed-author:JohnThomasT,
pubmed-author:MoenScottS,
pubmed-author:NoffsingerDavid MDM,
pubmed-author:PawlikJenniferJ,
pubmed-author:PetersonJohnny WJW,
pubmed-author:SawadaRitsukoR,
pubmed-author:ScholzWolfgang WWW,
pubmed-author:SircarJagadishJ,
pubmed-author:SowerLaurieL,
pubmed-author:StanberryLawrence RLR,
pubmed-author:TaorminaJoannaJ,
pubmed-author:WalbergKristin GKG,
pubmed-author:WenglikowskiAutumnA
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pubmed:issnType |
Print
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pubmed:volume |
75
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3414-24
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pubmed:dateRevised |
2011-5-25
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pubmed:meshHeading |
pubmed-meshheading:17452469-Administration, Inhalation,
pubmed-meshheading:17452469-Animals,
pubmed-meshheading:17452469-Anthrax,
pubmed-meshheading:17452469-Antibodies, Monoclonal,
pubmed-meshheading:17452469-Antigens, Bacterial,
pubmed-meshheading:17452469-Bacillus anthracis,
pubmed-meshheading:17452469-Bacterial Toxins,
pubmed-meshheading:17452469-Disease Models, Animal,
pubmed-meshheading:17452469-Humans,
pubmed-meshheading:17452469-Lung,
pubmed-meshheading:17452469-Rabbits,
pubmed-meshheading:17452469-Spores, Bacterial
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pubmed:year |
2007
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pubmed:articleTitle |
Human monoclonal antibody AVP-21D9 to protective antigen reduces dissemination of the Bacillus anthracis Ames strain from the lungs in a rabbit model.
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pubmed:affiliation |
Department of Microbiology and Immunology, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555-1070, USA. johnny.peterson@utmb.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, N.I.H., Extramural
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