17452404

Source:http://linkedlifedata.com/resource/pubmed/id/17452404

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0005802, umls-concept:C0009325, umls-concept:C0022646, umls-concept:C0022663, umls-concept:C0033268, umls-concept:C0205195, umls-concept:C0205250, umls-concept:C0332437, umls-concept:C1280500, umls-concept:C1517927, umls-concept:C1704256, umls-concept:C1881878
pubmed:issue	9
pubmed:dateCreated	2007-8-28
pubmed:abstractText	There is a correlation between renal graft rejection and blood glucose (BG) levels. Furthermore, diabetic patients may develop non-diabetic renal diseases, which in some circumstances progress rapidly. Since transforming growth factor-beta1 (TGF-beta) levels are elevated in many renal diseases, the accelerated progression may be due to interactions between glucose and locally produced TGF-beta1. Therefore, we investigated the effect of mild hyperglycaemia on glomerular morphology and collagen production in TGF-beta1 transgenic mice.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/8706402
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Blood Glucose, http://linkedlifedata.com/resource/pubmed/chemical/Collagen, http://linkedlifedata.com/resource/pubmed/chemical/Extracellular Matrix Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Extracellular Signal-Regulated MAP..., http://linkedlifedata.com/resource/pubmed/chemical/Peptide Hydrolases, http://linkedlifedata.com/resource/pubmed/chemical/Phosphoproteins, http://linkedlifedata.com/resource/pubmed/chemical/Protease Inhibitors, http://linkedlifedata.com/resource/pubmed/chemical/Transforming Growth Factor beta, http://linkedlifedata.com/resource/pubmed/chemical/Transforming Growth Factor beta1, http://linkedlifedata.com/resource/pubmed/chemical/betaIG-H3 protein
pubmed:status	MEDLINE
pubmed:month	Sep
pubmed:issn	0931-0509
pubmed:author	pubmed-author:KragSørenS, pubmed-author:NyengaardJens RJR, pubmed-author:WogensenLiseL
pubmed:issnType	Print
pubmed:volume	22
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	2485-96
pubmed:dateRevised	2009-11-19
pubmed:meshHeading	pubmed-meshheading:17452404-Animals, pubmed-meshheading:17452404-Blood Glucose, pubmed-meshheading:17452404-Body Weight, pubmed-meshheading:17452404-Collagen, pubmed-meshheading:17452404-Extracellular Matrix, pubmed-meshheading:17452404-Extracellular Matrix Proteins, pubmed-meshheading:17452404-Extracellular Signal-Regulated MAP Kinases, pubmed-meshheading:17452404-Gene Expression Regulation, pubmed-meshheading:17452404-Glomerular Basement Membrane, pubmed-meshheading:17452404-Glomerular Mesangium, pubmed-meshheading:17452404-Immunohistochemistry, pubmed-meshheading:17452404-Kidney Glomerulus, pubmed-meshheading:17452404-Male, pubmed-meshheading:17452404-Mice, pubmed-meshheading:17452404-Mice, Inbred C57BL, pubmed-meshheading:17452404-Peptide Hydrolases, pubmed-meshheading:17452404-Phosphoproteins, pubmed-meshheading:17452404-Protease Inhibitors, pubmed-meshheading:17452404-Transforming Growth Factor beta, pubmed-meshheading:17452404-Transforming Growth Factor beta1
pubmed:year	2007
pubmed:articleTitle	Combined effects of moderately elevated blood glucose and locally produced TGF-beta1 on glomerular morphology and renal collagen production.
pubmed:affiliation	Research Laboratory for Biochemical Pathology, Aarhus University Hospital, Aarhus C, Denmark. soeren.krag@ki.au.dk
pubmed:publicationType	Journal Article, Research Support, Non-U.S. Gov't