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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1-2
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pubmed:dateCreated |
2007-5-18
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pubmed:abstractText |
The antiviral activity of interferon-lambda (IFN-lambda) against several viruses has been reported, but it has not been investigated whether human IFN-lambda can affect replication of the hepatitis B virus (HBV) in human hepatocyte-derived cells. We found that replication of HBV in a human hepatoma cell line was reduced by approximately 30% following treatment with a high concentration of IFN-lambda. Furthermore, we showed that replication of HBV in another human hepatoma cell line was not suppressed by IFN-lambda. However, these cell lines showed a similar level of transcription for the heterodimeric IFN-lambda receptor and the IFN-lambda-induced antiviral proteins. Our results suggest that the antiviral activity of IFN-lambda against HBV may be limited in human cells.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0168-1702
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
126
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
245-9
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pubmed:dateRevised |
2008-5-15
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pubmed:meshHeading |
pubmed-meshheading:17451832-Antigens, Viral,
pubmed-meshheading:17451832-Cell Line, Tumor,
pubmed-meshheading:17451832-Cytokines,
pubmed-meshheading:17451832-Gene Expression,
pubmed-meshheading:17451832-Genome, Viral,
pubmed-meshheading:17451832-Hepatitis B virus,
pubmed-meshheading:17451832-Humans,
pubmed-meshheading:17451832-Interleukins,
pubmed-meshheading:17451832-Receptors, Interferon,
pubmed-meshheading:17451832-Recombinant Proteins,
pubmed-meshheading:17451832-Transcription, Genetic,
pubmed-meshheading:17451832-Virus Replication
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pubmed:year |
2007
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pubmed:articleTitle |
Effect of interferon-lambda on replication of hepatitis B virus in human hepatoma cells.
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pubmed:affiliation |
Department of Microbiology, Ajou University School of Medicine, Youngtongku Wonchondong San 5, Suwon 442-749, Republic of Korea.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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