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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2007-4-24
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pubmed:abstractText |
Alveolar bone resorption is a characteristic feature of periodontal diseases and involves removal of both the mineral and the organic constituents of the bone matrix, a process mainly carried out by multinucleated osteoclast cells. (-)-Epigallocatechin gallate, the main constituent of green tea polyphenols, has been reported to induce the apoptotic cell death of osteoclasts and to modulate caspase activation in various tumor cells. In the present study, we investigated the inhibitory effect of (-)-epigallocatechin gallate on osteoclast survival and examined if (-)-epigallocatechin gallate mediates osteoclast apoptosis via caspase activation.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
D
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0022-3484
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
42
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
212-8
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pubmed:meshHeading |
pubmed-meshheading:17451540-Acid Phosphatase,
pubmed-meshheading:17451540-Alveolar Process,
pubmed-meshheading:17451540-Amino Acid Chloromethyl Ketones,
pubmed-meshheading:17451540-Animals,
pubmed-meshheading:17451540-Apoptosis,
pubmed-meshheading:17451540-Bone Resorption,
pubmed-meshheading:17451540-Caspases,
pubmed-meshheading:17451540-Catechin,
pubmed-meshheading:17451540-Cell Line,
pubmed-meshheading:17451540-Cell Survival,
pubmed-meshheading:17451540-DNA Fragmentation,
pubmed-meshheading:17451540-Enzyme Activation,
pubmed-meshheading:17451540-Enzyme Inhibitors,
pubmed-meshheading:17451540-Isoenzymes,
pubmed-meshheading:17451540-Mice,
pubmed-meshheading:17451540-Osteoclasts,
pubmed-meshheading:17451540-RANK Ligand
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pubmed:year |
2007
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pubmed:articleTitle |
(-)-Epigallocatechin gallate induces apoptosis, via caspase activation, in osteoclasts differentiated from RAW 264.7 cells.
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pubmed:affiliation |
Department of Dentistry, College of Medicine, Kwandong University, Myongji Hospital, Goyang, Gyeonggi, Korea.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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