|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
10
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|
pubmed:dateCreated |
2007-5-10
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|
pubmed:abstractText |
6-phenylpurines were identified as novel, ATP-competitive inhibitors of protein kinase B (PKB/Akt) from a fragment-based screen and were rapidly progressed to potent compounds using iterative protein-ligand crystallography with a PKA-PKB chimeric protein. An elaborated lead compound showed cell growth inhibition and effects on cellular signaling pathways characteristic of PKB inhibition.
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pubmed:language |
eng
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pubmed:journal |
|
|
pubmed:citationSubset |
IM
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|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0022-2623
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pubmed:author |
|
|
pubmed:issnType |
Print
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|
pubmed:day |
17
|
|
pubmed:volume |
50
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
2289-92
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|
pubmed:dateRevised |
2009-11-19
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|
pubmed:meshHeading |
pubmed-meshheading:17451235-Adenosine Triphosphate,
pubmed-meshheading:17451235-Antineoplastic Agents,
pubmed-meshheading:17451235-Cell Line, Tumor,
pubmed-meshheading:17451235-Cell Proliferation,
pubmed-meshheading:17451235-Crystallography, X-Ray,
pubmed-meshheading:17451235-Cyclic AMP-Dependent Protein Kinases,
pubmed-meshheading:17451235-Drug Design,
pubmed-meshheading:17451235-Drug Screening Assays, Antitumor,
pubmed-meshheading:17451235-Humans,
pubmed-meshheading:17451235-Ligands,
pubmed-meshheading:17451235-Models, Molecular,
pubmed-meshheading:17451235-Protein Binding,
pubmed-meshheading:17451235-Protein Structure, Tertiary,
pubmed-meshheading:17451235-Proto-Oncogene Proteins c-akt,
pubmed-meshheading:17451235-Purines,
pubmed-meshheading:17451235-Recombinant Fusion Proteins,
pubmed-meshheading:17451235-Structure-Activity Relationship
|
|
pubmed:year |
2007
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|
pubmed:articleTitle |
Rapid evolution of 6-phenylpurine inhibitors of protein kinase B through structure-based design.
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|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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