Linked Life Data

17449820

Source:http://linkedlifedata.com/resource/pubmed/id/17449820

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
Pt 9
pubmed:dateCreated
2007-4-23
pubmed:abstractText
Probably all heritable traits, including disease susceptibility, are affected by interactions between mutations in multiple genes. We understand little, however, about how genes interact to produce phenotypes, and there is little power to detect interactions between genes in human population studies. An alternative approach towards understanding how mutations combine to produce phenotypes is to construct systematic genetic interaction networks in model organisms. Here I describe the methods that are being used to map genetic interactions in yeast and C. elegans, and the insights that these networks provide for human disease. I also discuss the mechanistic interpretation of genetic interaction networks, how genetic interactions can be used to understand gene function, and methods that have been developed to predict genetic interactions on a genome-wide scale.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0022-0949
pubmed:author
pubmed:issnType
Print
pubmed:volume
210
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1559-66
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Modelling genotype-phenotype relationships and human disease with genetic interaction networks.
pubmed:affiliation
EMBL/CRG Systems Biology Unit, Centre for Genomic Regulation, UPF, C/Dr Aiguader 88, Barcelona 08003, Spain. ben.lehner@crg.es
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't