Linked Life Data

17449181

Source:http://linkedlifedata.com/resource/pubmed/id/17449181

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-3
pubmed:dateCreated
2007-11-27
pubmed:abstractText
Oleoylethanolamide (OEA) is a natural fatty acid amide that mainly modulates feeding and energy homeostasis by binding to peroxisome proliferator-activated receptor-alpha (PPAR-alpha) [Rodríguez de Fonseca F, Navarro M, Gómez R, Escuredo L, Navas F, Fu J, et al. An anorexic lipid mediator regulated by feeding. Nature 2001;414:209-12; Fu J, Gaetani S, Oveisi F, Lo Verme J, Serrano A, Rodríguez de Fonseca F, et al. Oleoylethanolamide regulates feeding and body weight through activation of the nuclear receptor PPAR-alpha. Nature 2003;425:90-3]. Additionally, it has been proposed that OEA could act via other receptors, including the vanilloid receptor (TRPV1) [Wang X, Miyares RL, Ahern GP. Oleoylethanolamide excites vagal sensory neurones, induces visceral pain and reduces short-term food intake in mice via capsaicin receptor TRPV1. J Physiol 2005;564:541-7.] or the GPR119 receptor [Overton HA, Babbs AJ, Doel SM, Fyfe MC, Gardner LS, Griffin G, et al. Deorphanization of a G protein-coupled receptor for oleoylethanolamide and its use in the discovery of small-molecule hypophagic agents. Cell Metab 2006;3:167-175], suggesting that OEA might subserve other physiological roles, including pain perception. We have evaluated the effect of OEA in two types of nociceptive responses evoked by visceral and inflammatory pain in rodents. Our results suggest that OEA has analgesic properties reducing the nociceptive responses produced by administration of acetic acid and formalin in two experimental animal models. Additional research was performed to investigate the mechanisms underlying this analgesic effect. To this end, we evaluated the actions of OEA in mice null for the PPAR-alpha receptor gene and compared its actions with those of PPAR-alpha receptor wild-type animal. We also compared the effect of MK-801 in order to evaluate the role of NMDA receptor in this analgesia. Our data showed that OEA reduced visceral and inflammatory responses through a PPAR-alpha-activation independent mechanism. Co-administration of subanalgesic doses of MK-801 and OEA produced an analgesic effect, suggesting the participation of glutamatergic transmission in the antinociceptive effect of OEA. This study represents a novel approach to the examination of the effectiveness of OEA in nociceptive responses and provides a framework for understanding its biological functions and endogenous targets in visceral and inflammatory pain.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
1872-6623
pubmed:author
pubmed:issnType
Electronic
pubmed:day
15
pubmed:volume
133
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
99-110
pubmed:meshHeading
pubmed-meshheading:17449181-Analgesics, pubmed-meshheading:17449181-Animals, pubmed-meshheading:17449181-Anticholesteremic Agents, pubmed-meshheading:17449181-Behavior, Animal, pubmed-meshheading:17449181-Disease Models, Animal, pubmed-meshheading:17449181-Dizocilpine Maleate, pubmed-meshheading:17449181-Dose-Response Relationship, Drug, pubmed-meshheading:17449181-Drug Interactions, pubmed-meshheading:17449181-Excitatory Amino Acid Antagonists, pubmed-meshheading:17449181-Exploratory Behavior, pubmed-meshheading:17449181-Inflammation, pubmed-meshheading:17449181-Male, pubmed-meshheading:17449181-Mice, pubmed-meshheading:17449181-Mice, Knockout, pubmed-meshheading:17449181-Morphine, pubmed-meshheading:17449181-Oleic Acids, pubmed-meshheading:17449181-PPAR gamma, pubmed-meshheading:17449181-Pain, pubmed-meshheading:17449181-Pain Measurement, pubmed-meshheading:17449181-Pyrimidines
pubmed:year
2007
pubmed:articleTitle
Analgesic properties of oleoylethanolamide (OEA) in visceral and inflammatory pain.
pubmed:affiliation
Fundación IMABIS, Unidad de Investigación, Hospital Universitario Carlos Haya, Málaga 29010, Spain.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't