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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
2007-6-4
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pubmed:abstractText |
A series of quinazolinone-derived inhibitors of the CXCR3 receptor have been synthesized and their affinity for the receptor evaluated. Compounds were evaluated in a (125)I-IP10 displacement assay and in in vitro cell migration assays to IP10, ITAC, and MIG using human peripheral blood mononuclear cells.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/CXCR3 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Cxcr3 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/IP10-Mig receptor,
http://linkedlifedata.com/resource/pubmed/chemical/ITAC peptide,
http://linkedlifedata.com/resource/pubmed/chemical/Intercellular Signaling Peptides...,
http://linkedlifedata.com/resource/pubmed/chemical/Iodine Radioisotopes,
http://linkedlifedata.com/resource/pubmed/chemical/Oligopeptides,
http://linkedlifedata.com/resource/pubmed/chemical/Quinazolinones,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, CXCR3,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Chemokine,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cytokine
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0960-894X
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pubmed:author |
pubmed-author:CollinsTassieT,
pubmed-author:DairaghiDanD,
pubmed-author:DanaoJayJ,
pubmed-author:EbsworthKarenK,
pubmed-author:FuZiceZ,
pubmed-author:GEARJJ,
pubmed-author:HuangAlanA,
pubmed-author:JohnsonMichaelM,
pubmed-author:KumerJeffJ,
pubmed-author:LawrenceChrisC,
pubmed-author:LiAn-RongAR,
pubmed-author:LiuJiwenJ,
pubmed-author:MarcusAndrewA,
pubmed-author:MedinaJulioJ,
pubmed-author:MiaoShichangS,
pubmed-author:SablanEmmanuelE,
pubmed-author:SchallThomasT,
pubmed-author:SullivanTimT,
pubmed-author:TonnGeorgeG,
pubmed-author:WangXuemeiX,
pubmed-author:XuQinggeQ,
pubmed-author:ZhuLiushengL
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
17
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3339-43
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:17448658-Animals,
pubmed-meshheading:17448658-Cell Culture Techniques,
pubmed-meshheading:17448658-Cell Movement,
pubmed-meshheading:17448658-Humans,
pubmed-meshheading:17448658-Intercellular Signaling Peptides and Proteins,
pubmed-meshheading:17448658-Iodine Radioisotopes,
pubmed-meshheading:17448658-Leukocytes, Mononuclear,
pubmed-meshheading:17448658-Mice,
pubmed-meshheading:17448658-Models, Chemical,
pubmed-meshheading:17448658-Oligopeptides,
pubmed-meshheading:17448658-Quinazolinones,
pubmed-meshheading:17448658-Radioligand Assay,
pubmed-meshheading:17448658-Receptors, CXCR3,
pubmed-meshheading:17448658-Receptors, Chemokine,
pubmed-meshheading:17448658-Receptors, Cytokine,
pubmed-meshheading:17448658-Structure-Activity Relationship
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pubmed:year |
2007
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pubmed:articleTitle |
Discovery and optimization of a series of quinazolinone-derived antagonists of CXCR3.
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pubmed:affiliation |
Amgen Inc., 1120 Veterans Boulevard, South San Francisco, CA 94080, USA.
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pubmed:publicationType |
Journal Article
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