|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0007407,
umls-concept:C0025646,
umls-concept:C0036341,
umls-concept:C0042285,
umls-concept:C0429403,
umls-concept:C1280500,
umls-concept:C1417708,
umls-concept:C1423613,
umls-concept:C1539081,
umls-concept:C1705525,
umls-concept:C1882417,
umls-concept:C2936327
|
|
pubmed:issue |
7
|
|
pubmed:dateCreated |
2007-9-14
|
|
pubmed:abstractText |
Studies have implicated prefrontal dopamine in cortical information filtering. Deficit in stimulus filtering, an endophenotype of schizophrenia, can be demonstrated using the auditory P50 paired-click gating paradigm. The role of prefrontal dopamine on P50 gating was investigated, using catechol-O-methyltransferase (COMT) valine (val)(158)methionine (met) polymorphism as a predictor of prefrontal dopamine activity.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Oct
|
|
pubmed:issn |
0006-3223
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
1
|
|
pubmed:volume |
62
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
822-5
|
|
pubmed:dateRevised |
2007-12-3
|
|
pubmed:meshHeading |
pubmed-meshheading:17448448-Adult,
pubmed-meshheading:17448448-Amino Acid Substitution,
pubmed-meshheading:17448448-Antipsychotic Agents,
pubmed-meshheading:17448448-Catechol O-Methyltransferase,
pubmed-meshheading:17448448-Evoked Potentials, Auditory,
pubmed-meshheading:17448448-Female,
pubmed-meshheading:17448448-Humans,
pubmed-meshheading:17448448-Male,
pubmed-meshheading:17448448-Methionine,
pubmed-meshheading:17448448-Middle Aged,
pubmed-meshheading:17448448-Phenotype,
pubmed-meshheading:17448448-Polymorphism, Genetic,
pubmed-meshheading:17448448-Regression Analysis,
pubmed-meshheading:17448448-Schizophrenia,
pubmed-meshheading:17448448-Smoking,
pubmed-meshheading:17448448-Valine
|
|
pubmed:year |
2007
|
|
pubmed:articleTitle |
Effect of catechol O-methyltransferase val(158)met polymorphism on the p50 gating endophenotype in schizophrenia.
|
|
pubmed:affiliation |
Department of Psychiatry, University of New Mexico, Albuquerque, New Mexico 87108, USA. brettlu@yahoo.com
|
|
pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
|
