17446071

Source:http://linkedlifedata.com/resource/pubmed/id/17446071

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0205314, umls-concept:C0206529, umls-concept:C0243076, umls-concept:C0449560, umls-concept:C0679622, umls-concept:C1705542, umls-concept:C1880355
pubmed:issue	11
pubmed:dateCreated	2007-5-14
pubmed:abstractText	Investigation of a series of heterobicyclic compounds with essential pharmacophoric features of the metabotropic glutamate receptor 5 (mGluR5) antagonists MPEP and MTEP provided novel structural templates with sub-micromolar affinities at the mGluR5.
pubmed:grant	http://linkedlifedata.com/resource/pubmed/grant/Z01 DA000488-02
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pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/9107377
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/3-((2-methyl-1,3-thiazol-4-yl)ethyny..., http://linkedlifedata.com/resource/pubmed/chemical/6-methyl-2-(phenylethynyl)pyridine, http://linkedlifedata.com/resource/pubmed/chemical/Bicyclo Compounds, Heterocyclic, http://linkedlifedata.com/resource/pubmed/chemical/Pyridines, http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Metabotropic Glutamate, http://linkedlifedata.com/resource/pubmed/chemical/Thiazoles, http://linkedlifedata.com/resource/pubmed/chemical/metabotropic glutamate receptor 5
pubmed:status	MEDLINE
pubmed:month	Jun
pubmed:issn	0960-894X
pubmed:author	pubmed-author:KulkarniSantosh SSS, pubmed-author:NewmanAmy HauckAH
pubmed:issnType	Print
pubmed:day	1
pubmed:volume	17
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	2987-91
pubmed:dateRevised	2009-11-18
pubmed:meshHeading	pubmed-meshheading:17446071-Bicyclo Compounds, Heterocyclic, pubmed-meshheading:17446071-Humans, pubmed-meshheading:17446071-Hydrolysis, pubmed-meshheading:17446071-Pyridines, pubmed-meshheading:17446071-Receptors, Metabotropic Glutamate, pubmed-meshheading:17446071-Structure-Activity Relationship, pubmed-meshheading:17446071-Thiazoles
pubmed:year	2007
pubmed:articleTitle	Discovery of heterobicyclic templates for novel metabotropic glutamate receptor subtype 5 antagonists.
pubmed:affiliation	Medicinal Chemistry Section, National Institute on Drug Abuse, Intramural Research Program, NIH, DHHS, Baltimore, MD 21224, USA.
pubmed:publicationType	Journal Article, Research Support, N.I.H., Extramural