Source:http://linkedlifedata.com/resource/pubmed/id/17445532
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
2007-4-20
|
| pubmed:abstractText |
In patients with chronic renal failure undergoing hemodialysis (HD), silent cerebral infarctions (SCIs) are associated with high mortality. Levels of hepatocyte growth factor (HGF) increase with renal dysfunction and may be a novel predictor of cerebrovascular events. We examined if HGF is a predictor of SCI in HD patients. Brain magnetic resonance imaging findings were used to divide 50 patients undergoing HD into 2 groups, a group with SCI (age, 61 +/- 8 years, mean +/- SD; n = 27) and a group without SCI (age, 60 +/- 7 years; n = 23). These patients received 24-hour ambulatory blood pressure monitoring. The number of patients with diabetes or hypertension was not different between the 2 groups. We made the following observations: (1) The percentage of smokers was higher in the group with SCI than in the group without SCI (P < .05). (2) Plasma levels of high-density lipoprotein cholesterol were lower and HGF levels were higher in the group with SCI compared with the group without SCI (P < .05 and P < .005, respectively). (3) Systolic ambulatory blood pressure and mean heart rate at night were higher in the group with SCI than in the group without SCI (P < .05). Multiple logistic regression analysis identified HGF as a significant risk factor for SCI (odds ratio, 1.89; 95% confidence interval, 1.57-3.38; P < .005). Our findings indicate that HGF may be a novel useful predictor of SCI in patients with chronic renal failure undergoing HD.
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| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
May
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| pubmed:issn |
0026-0495
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| pubmed:author |
pubmed-author:AnanFutoshiF,
pubmed-author:EshimaNobuokiN,
pubmed-author:ImagawaMasaharuM,
pubmed-author:MasakiTakayukiT,
pubmed-author:NawataTomokoT,
pubmed-author:SaikawaTetsunoriT,
pubmed-author:ShimomuraTsuyoshiT,
pubmed-author:TakahashiNaohikoN,
pubmed-author:YonemochiHidetoshiH,
pubmed-author:YoshimatsuHironobuH
|
| pubmed:issnType |
Print
|
| pubmed:volume |
56
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
593-8
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| pubmed:meshHeading |
pubmed-meshheading:17445532-Blood Pressure Monitoring, Ambulatory,
pubmed-meshheading:17445532-Brain,
pubmed-meshheading:17445532-Cerebral Infarction,
pubmed-meshheading:17445532-Echocardiography, Doppler,
pubmed-meshheading:17445532-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:17445532-Female,
pubmed-meshheading:17445532-Hepatocyte Growth Factor,
pubmed-meshheading:17445532-Humans,
pubmed-meshheading:17445532-Kidney Failure, Chronic,
pubmed-meshheading:17445532-Logistic Models,
pubmed-meshheading:17445532-Magnetic Resonance Imaging,
pubmed-meshheading:17445532-Male,
pubmed-meshheading:17445532-Middle Aged,
pubmed-meshheading:17445532-Predictive Value of Tests,
pubmed-meshheading:17445532-Renal Dialysis
|
| pubmed:year |
2007
|
| pubmed:articleTitle |
Predictors for silent cerebral infarction in patients with chronic renal failure undergoing hemodialysis.
|
| pubmed:affiliation |
Department of Cardiology, Oita Red Cross Hospital, Oita, Japan. anan-f@med.oita-u.ac.jp
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| pubmed:publicationType |
Journal Article
|