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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
2007-5-10
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pubmed:abstractText |
A series of N-substituted-quinolinone-3-aminoamides and their hybrids containing the alpha-lipoic acid functionality were designed and synthesized as potential bifunctional agents combining antioxidant and anti-inflammatory activity. The new compounds were evaluated for their antioxidant activity and for their ability to inhibit in vitro lipoxygenase as well as for their anti-inflammatory activity in vivo. In general, the derivatives were found to be potent antioxidant or anti-inflammatory agents. The results are discussed in terms of structure-activity relationships and an attempt is made to define the structural features required for activity.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/2,2-diphenyl-1-picrylhydrazyl,
http://linkedlifedata.com/resource/pubmed/chemical/Amides,
http://linkedlifedata.com/resource/pubmed/chemical/Anti-Inflammatory Agents...,
http://linkedlifedata.com/resource/pubmed/chemical/Antioxidants,
http://linkedlifedata.com/resource/pubmed/chemical/Biphenyl Compounds,
http://linkedlifedata.com/resource/pubmed/chemical/Carrageenan,
http://linkedlifedata.com/resource/pubmed/chemical/Dimethyl Sulfoxide,
http://linkedlifedata.com/resource/pubmed/chemical/Hydrazines,
http://linkedlifedata.com/resource/pubmed/chemical/Hydroxyl Radical,
http://linkedlifedata.com/resource/pubmed/chemical/Lipoxygenase Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Picrates,
http://linkedlifedata.com/resource/pubmed/chemical/Quinolones,
http://linkedlifedata.com/resource/pubmed/chemical/Thioctic Acid
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0022-2623
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
17
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pubmed:volume |
50
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2450-8
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:17444626-Amides,
pubmed-meshheading:17444626-Animals,
pubmed-meshheading:17444626-Anti-Inflammatory Agents, Non-Steroidal,
pubmed-meshheading:17444626-Antioxidants,
pubmed-meshheading:17444626-Biphenyl Compounds,
pubmed-meshheading:17444626-Carrageenan,
pubmed-meshheading:17444626-Dimethyl Sulfoxide,
pubmed-meshheading:17444626-Edema,
pubmed-meshheading:17444626-Female,
pubmed-meshheading:17444626-Hydrazines,
pubmed-meshheading:17444626-Hydroxyl Radical,
pubmed-meshheading:17444626-Lipoxygenase Inhibitors,
pubmed-meshheading:17444626-Male,
pubmed-meshheading:17444626-Oxidation-Reduction,
pubmed-meshheading:17444626-Picrates,
pubmed-meshheading:17444626-Quinolones,
pubmed-meshheading:17444626-Rats,
pubmed-meshheading:17444626-Rats, Inbred F344,
pubmed-meshheading:17444626-Structure-Activity Relationship,
pubmed-meshheading:17444626-Thioctic Acid
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pubmed:year |
2007
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pubmed:articleTitle |
Design and synthesis of novel quinolinone-3-aminoamides and their alpha-lipoic acid adducts as antioxidant and anti-inflammatory agents.
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pubmed:affiliation |
Laboratory of Organic Chemistry, School of Chemical Engineering, National Technical University of Athens, Zorgafou Campus, GR 157 73, Athens, Greece. adetsi@chemeng.ntua.gr
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pubmed:publicationType |
Journal Article
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