Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
2007-7-30
pubmed:abstractText
The ultraviolet (UV) radiation in sunlight induces skin cancer development. Skin cancer is the most common form of human neoplasia. Estimates suggest that in excess of 1.5 million new cases of skin cancer (www.cancer.org/statistics) will be diagnosed in the United States this year. Fortunately, because of their highly visible location, skin cancers are more rapidly diagnosed and more easily treated than other types of cancer. Be that as it may, approximately 10,000 Americans a year die from skin cancer, and the cost of treating skin cancer in the United States (both melanoma and non-melanoma skin cancer) is estimated to be in excess of $2.9 billion a year. In addition to causing skin cancer, UV radiation is also immune suppressive. In fact, data from studies with both experimental animals and biopsy proven skin cancer patients suggest that there is an association between the immune suppressive effects of UV radiation and its carcinogenic potential. Recent studies in my laboratory have focused on understanding the initial molecular events that induce immune suppression. We made two novel observations: first UV-induced keratinocyte-derived platelet activating factor plays a role in the induction of immune suppression. Second, cis-urocanic acid, a skin-derived immunosuppressive compound mediates immune suppression by binding to serotonin receptors on target cells. Recent findings suggest that blocking the binding of these compounds to their receptors not only inhibits UV-induced immune suppression but it also interferes with skin cancer induction.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/17443748-10233769, http://linkedlifedata.com/resource/pubmed/commentcorrection/17443748-10506108, http://linkedlifedata.com/resource/pubmed/commentcorrection/17443748-10945373, http://linkedlifedata.com/resource/pubmed/commentcorrection/17443748-10975830, http://linkedlifedata.com/resource/pubmed/commentcorrection/17443748-11714785, http://linkedlifedata.com/resource/pubmed/commentcorrection/17443748-11805144, http://linkedlifedata.com/resource/pubmed/commentcorrection/17443748-15020195, http://linkedlifedata.com/resource/pubmed/commentcorrection/17443748-15677341, http://linkedlifedata.com/resource/pubmed/commentcorrection/17443748-15748647, http://linkedlifedata.com/resource/pubmed/commentcorrection/17443748-16936256, http://linkedlifedata.com/resource/pubmed/commentcorrection/17443748-17085585, http://linkedlifedata.com/resource/pubmed/commentcorrection/17443748-2230216, http://linkedlifedata.com/resource/pubmed/commentcorrection/17443748-4139281, http://linkedlifedata.com/resource/pubmed/commentcorrection/17443748-6223114, http://linkedlifedata.com/resource/pubmed/commentcorrection/17443748-7480130, http://linkedlifedata.com/resource/pubmed/commentcorrection/17443748-8288907, http://linkedlifedata.com/resource/pubmed/commentcorrection/17443748-9558081, http://linkedlifedata.com/resource/pubmed/commentcorrection/17443748-9668065
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0899-1987
pubmed:author
pubmed:issnType
Print
pubmed:volume
46
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
629-33
pubmed:dateRevised
2011-3-21
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Sunlight and skin cancer: lessons from the immune system.
pubmed:affiliation
Department of Immunology and the Center for Cancer Immunology Research, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA.
pubmed:publicationType
Journal Article, Review, Research Support, N.I.H., Extramural