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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
13
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pubmed:dateCreated |
2007-6-14
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pubmed:abstractText |
Human immunodeficiency virus type 1 (HIV-1) infection causes apoptosis of infected CD4 T cells as well as uninfected (bystander) CD4 and CD8 T cells. It remains unknown what signals cause infected cells to die. We demonstrate that HIV-1 protease specifically cleaves procaspase 8 to create a novel fragment termed casp8p41, which independently induces apoptosis. casp8p41 is specific to HIV-1 protease-induced death but not other caspase 8-dependent death stimuli. In HIV-1-infected patients, casp8p41 is detected only in CD4(+) T cells, predominantly in the CD27(+) memory subset, its presence increases with increasing viral load, and it colocalizes with both infected and apoptotic cells. These data indicate that casp8p41 independently induces apoptosis and is a specific product of HIV-1 protease which may contribute to death of HIV-1-infected cells.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/17442709-10781611,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17442709-11238596,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17442709-11606767,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17442709-11714838,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17442709-11986671,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17442709-12370191,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17442709-12404116,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17442709-12620239,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17442709-12766761,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17442709-12885763,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17442709-1346269,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17442709-14722271,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17442709-15365095,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17442709-15365096,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17442709-1540415,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17442709-15629450,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17442709-15781615,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17442709-15793562,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17442709-15793563,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17442709-16492778,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17442709-16682056,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17442709-16862156,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17442709-17147474,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17442709-1726101,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17442709-1801737,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17442709-2034693,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17442709-2201025,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17442709-7009747,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17442709-7585008,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17442709-7773174,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17442709-8084015,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17442709-8136021,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17442709-8424456,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17442709-8523526,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17442709-8789141,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17442709-8790371
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0022-538X
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pubmed:author |
pubmed-author:BadleyAndrew DAD,
pubmed-author:BrenGary DGD,
pubmed-author:BrenchleyJason MJM,
pubmed-author:DouekDaniel CDC,
pubmed-author:KovacsColin MCM,
pubmed-author:LoutfyMona RMR,
pubmed-author:NieZilinZ,
pubmed-author:SchimnichAlicia AlgecirasAA,
pubmed-author:SchneppleDavid JDJ,
pubmed-author:TrushinSergey ASA,
pubmed-author:VlahakisStacey RSR,
pubmed-author:WarrenSarahS
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pubmed:issnType |
Print
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pubmed:volume |
81
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
6947-56
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:17442709-Antigens, CD27,
pubmed-meshheading:17442709-Apoptosis,
pubmed-meshheading:17442709-CD4-Positive T-Lymphocytes,
pubmed-meshheading:17442709-CD8-Positive T-Lymphocytes,
pubmed-meshheading:17442709-Caspase 8,
pubmed-meshheading:17442709-HIV Infections,
pubmed-meshheading:17442709-HIV Protease,
pubmed-meshheading:17442709-HIV-1,
pubmed-meshheading:17442709-Humans,
pubmed-meshheading:17442709-Immunologic Memory,
pubmed-meshheading:17442709-Jurkat Cells
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pubmed:year |
2007
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pubmed:articleTitle |
Human immunodeficiency virus type 1 protease cleaves procaspase 8 in vivo.
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pubmed:affiliation |
Division of Infectious Diseases, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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