Linked Life Data

17442558

Source:http://linkedlifedata.com/resource/pubmed/id/17442558

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2007-5-11
pubmed:abstractText
The original definition of NK cells was based on their 'natural' cytolytic response against tumor cells and virus-infected cells in the absence of specific immunization. However, the term 'natural killer' reflects neither the education/maturation requirements before NK cells can kill nor the entirety of their biological functions. In light of new functional assays, genetic models and genomics analysis, we propose a more accurate definition of NK cells. This definition includes the phenotypical identification of NK cells as CD3(-)NKp46(+) cells across mammalian species. In general, this attempt to redefine NK cells also highlights the need to update the operational definition of cell types in the post-genomic area.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0952-7915
pubmed:author
pubmed:issnType
Print
pubmed:volume
19
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
365-72
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Natural killer cells: from CD3(-)NKp46(+) to post-genomics meta-analyses.
pubmed:affiliation
Centre d'Immunologie de Marseille-Luminy, Université de la Mediterranée, Case 906, 13288 Marseille cedex 9, France. vivier@ciml.univ-mrs.fr
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't