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rdf:type |
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lifeskim:mentions |
umls-concept:C0001613,
umls-concept:C0007776,
umls-concept:C0022655,
umls-concept:C0027651,
umls-concept:C0030685,
umls-concept:C0033371,
umls-concept:C0034834,
umls-concept:C0085295,
umls-concept:C0205252,
umls-concept:C0332281,
umls-concept:C0391871,
umls-concept:C0680255,
umls-concept:C0814999,
umls-concept:C1283071,
umls-concept:C1963578
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pubmed:issue |
1-2
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pubmed:dateCreated |
2007-5-28
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pubmed:abstractText |
The soluble factors produced either by Ehrlich's ascites carcinoma (EAC) or thymic adherent cells (TAC) of tumor-bearing mice comprising of CD11b(+) and CD11c(+) antigen-presenting cells caused a sharp decrease in prolactin (PRL)-induced ConA-mediated effect on survival of PNA(+) thymocytes. Similar suppression of PRL-induced effect was observed when the cells were cocultured with TAC of EAC-bearing mice. Anti-IL-10 antibody could reverse the PRL inability to induce ConA-mediated effect on PNA(+) thymocyte survival, indicating the presence of IL-10 in EAC culture supernatant (EAC sup) and thymic microenvironment. IL-10 could block PRL-induced proliferation of PNA(+) thymocytes without affecting spontaneous apoptosis. IL-10 altered the expression of the long-form (LF) of PRL-R and reduced the PRL binding of the cells, suggesting down-regulation of the PRL effect on PNA(+) thymocyte by the cytokine. Induction of tumor, which was found to increase the IL-10 secretion by TAC, also modified the PRL-R (LF) to PRL-R (SF). Since PRL plays a role in survival, proliferation and differentiation of lymphoid progenitor cells, the tuning of PRL action by IL-10 may be a possible mechanism of depletion of immature cortical thymocytes and thymic atrophy in tumor-bearing mice.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Culture Media, Conditioned,
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Concatenated,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-10,
http://linkedlifedata.com/resource/pubmed/chemical/Peanut Agglutinin,
http://linkedlifedata.com/resource/pubmed/chemical/Prolactin,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Prolactin
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0165-5728
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
186
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
112-20
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pubmed:meshHeading |
pubmed-meshheading:17442407-Animals,
pubmed-meshheading:17442407-Apoptosis,
pubmed-meshheading:17442407-Carcinoma, Ehrlich Tumor,
pubmed-meshheading:17442407-Cell Cycle,
pubmed-meshheading:17442407-Cells, Cultured,
pubmed-meshheading:17442407-Coculture Techniques,
pubmed-meshheading:17442407-Culture Media, Conditioned,
pubmed-meshheading:17442407-DNA, Concatenated,
pubmed-meshheading:17442407-Dose-Response Relationship, Drug,
pubmed-meshheading:17442407-Down-Regulation,
pubmed-meshheading:17442407-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:17442407-Female,
pubmed-meshheading:17442407-Flow Cytometry,
pubmed-meshheading:17442407-Interleukin-10,
pubmed-meshheading:17442407-Mice,
pubmed-meshheading:17442407-Neoplasm Transplantation,
pubmed-meshheading:17442407-Peanut Agglutinin,
pubmed-meshheading:17442407-Prolactin,
pubmed-meshheading:17442407-RNA, Messenger,
pubmed-meshheading:17442407-Receptors, Prolactin,
pubmed-meshheading:17442407-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:17442407-Thymus Gland
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pubmed:year |
2007
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pubmed:articleTitle |
Tumor associated release of interleukin-10 alters the prolactin receptor and down-regulates prolactin responsiveness of immature cortical thymocytes.
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pubmed:affiliation |
Department of Immunoregulation and Immunodiagnostics, Chittaranjan National Cancer Institute, 37, S. P. Mukherjee Road, Kolkata-700 026, West Bengal, India.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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