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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
|
| pubmed:dateCreated |
1992-1-10
|
| pubmed:abstractText |
Interaction of active and UV-inactivated vaccinia virus at high multiplicity caused cytological changes and inhibition in cellular protein and DNA synthesis, thus arresting the multiplication of Burkitt-lymphoma-derived Daudi cells and eventually killing the cells. Adsorption to the cells but the lack of penetration was evident by immunofluorescence, electron microscopy and [3H]thymidine-labeled virus incorporation. Viral DNA synthesis or virus replication was not demonstrated. Thus, it appears that the massive adsorption of viral particles, active or UV-inactivated, or possibly a "toxic" component that resides in the virion, damages the plasma membrane and may be responsible for killing the cells by a mechanism of lysis from without.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0171-5216
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
117
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
561-7
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:1744162-Animals,
pubmed-meshheading:1744162-Burkitt Lymphoma,
pubmed-meshheading:1744162-Cell Line,
pubmed-meshheading:1744162-Cell Membrane Permeability,
pubmed-meshheading:1744162-Cell Survival,
pubmed-meshheading:1744162-Cercopithecus aethiops,
pubmed-meshheading:1744162-Cytotoxicity, Immunologic,
pubmed-meshheading:1744162-DNA,
pubmed-meshheading:1744162-Dose-Response Relationship, Radiation,
pubmed-meshheading:1744162-Fluorescent Antibody Technique,
pubmed-meshheading:1744162-Humans,
pubmed-meshheading:1744162-Immunotherapy,
pubmed-meshheading:1744162-Microscopy, Electron, Scanning,
pubmed-meshheading:1744162-Protein Biosynthesis,
pubmed-meshheading:1744162-Ultraviolet Rays,
pubmed-meshheading:1744162-Vaccines, Inactivated,
pubmed-meshheading:1744162-Vaccinia virus
|
| pubmed:year |
1991
|
| pubmed:articleTitle |
Killing of Burkitt-lymphoma-derived Daudi cells by ultraviolet-inactivated vaccinia virus.
|
| pubmed:affiliation |
Department of Virology, Hebrew University-Hadassah Medical School, Jerusalem, Israel.
|
| pubmed:publicationType |
Journal Article,
In Vitro
|