Linked Life Data

17439705

Source:http://linkedlifedata.com/resource/pubmed/id/17439705

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2007-4-18
pubmed:abstractText
The superoxide dismutase 1(G93A G1H) (SOD1(G93A G1H)) transgenic mouse is a model of familial human amyotrophic lateral sclerosis (ALS) that has progressive neurodegeneration within the spinal cord and brainstem. In this study, we investigated the number and differentiation of neural precursor cells (NPCs). Nestin-positive NPCs were rarely seen in the nervous system of wild type controls or pre-disease mice at post-natal days 30 and 60. With disease onset on post-natal day 90, nestin labeled NPCs proliferated preferentially in the brainstem with maximal number and density at post-natal day 120. NPCs did not double-label with CNPase or O(4) markers of oligodendrocytes. The majority of the NPCs co-labeled with the astrocyte maker glial fibrillary acidic protein (GFAP) and a small number with the neuronal marker NeuN. At disease onset, 73 and 10% of NPCs co-expressed GFAP and NeuN respectively while at severe disease stage, 80 and 8% of the NPCs co-expressed GFAP and NeuN. Proliferating cell nuclear antigen (PCNA) was used to confirm that at least some of these cells undergo mitosis. Future studies could be directed at controlling the differentiation of these endogenous NPCs into neurons and astrocytes in order to ameliorate the degeneration within the brainstem of the ALS mouse.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0161-6412
pubmed:author
pubmed:issnType
Print
pubmed:volume
29
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
204-9
pubmed:meshHeading
pubmed-meshheading:17439705-Amyotrophic Lateral Sclerosis, pubmed-meshheading:17439705-Animals, pubmed-meshheading:17439705-Astrocytes, pubmed-meshheading:17439705-Biological Markers, pubmed-meshheading:17439705-Brain Stem, pubmed-meshheading:17439705-Cell Differentiation, pubmed-meshheading:17439705-Cell Proliferation, pubmed-meshheading:17439705-Disease Models, Animal, pubmed-meshheading:17439705-Female, pubmed-meshheading:17439705-Glial Fibrillary Acidic Protein, pubmed-meshheading:17439705-Humans, pubmed-meshheading:17439705-Intermediate Filament Proteins, pubmed-meshheading:17439705-Male, pubmed-meshheading:17439705-Mice, pubmed-meshheading:17439705-Mice, Transgenic, pubmed-meshheading:17439705-Nerve Degeneration, pubmed-meshheading:17439705-Nerve Regeneration, pubmed-meshheading:17439705-Nerve Tissue Proteins, pubmed-meshheading:17439705-Neuronal Plasticity, pubmed-meshheading:17439705-Neurons, pubmed-meshheading:17439705-Nuclear Proteins, pubmed-meshheading:17439705-Proliferating Cell Nuclear Antigen, pubmed-meshheading:17439705-Stem Cells, pubmed-meshheading:17439705-Superoxide Dismutase
pubmed:year
2007
pubmed:articleTitle
Increased number and differentiation of neural precursor cells in the brainstem of superoxide dismutase 1(G93A) (G1H) transgenic mouse model of amyotrophic lateral sclerosis.
pubmed:affiliation
Department of Laboratory Medicine, Tianjin First Central Hospital, Tianjin 300192, China.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't