17438272

Source:http://linkedlifedata.com/resource/pubmed/id/17438272

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0205360, umls-concept:C0205390, umls-concept:C1707418, umls-concept:C1709347, umls-concept:C1948027
pubmed:issue	17
pubmed:dateCreated	2007-4-25
pubmed:abstractText	Accuracy in cellular function has to be achieved despite random fluctuations (noise) in the concentrations of different molecular constituents inside and outside the cell. The circadian oscillator in cyanobacteria is an example of resilience to noise. This resilience could be either the consequence of intercellular communication or the intrinsic property of the built-in biochemical network. Here we investigate the intercellular coupling hypothesis. A short theoretical depiction of interacting noisy phase oscillators, confirmed by numerical simulations, allows us to discriminate the effect of coupling from noise. Experimentally, by studying the phase of concurrent populations of different initial phases, we evaluate a very small upper limit of the intercellular coupling strength. In addition, in situ entrainment experiments confirm our ability to detect a coupling of the circadian oscillator to an external force and to describe explicitly the dynamic change of the mean phase. We demonstrate, therefore, that the cyanobacterial clock stability is a built-in property as the intercellular coupling effect is negligible.
pubmed:commentsCorrections	http://linkedlifedata.com/resource/pubmed/commentcorrection/17438272-10348865, http://linkedlifedata.com/resource/pubmed/commentcorrection/17438272-14749492, http://linkedlifedata.com/resource/pubmed/commentcorrection/17438272-14964702, http://linkedlifedata.com/resource/pubmed/commentcorrection/17438272-15229601, http://linkedlifedata.com/resource/pubmed/commentcorrection/17438272-15550250, http://linkedlifedata.com/resource/pubmed/commentcorrection/17438272-15550625, http://linkedlifedata.com/resource/pubmed/commentcorrection/17438272-15620658, http://linkedlifedata.com/resource/pubmed/commentcorrection/17438272-15738976, http://linkedlifedata.com/resource/pubmed/commentcorrection/17438272-15831759, http://linkedlifedata.com/resource/pubmed/commentcorrection/17438272-15951747, http://linkedlifedata.com/resource/pubmed/commentcorrection/17438272-16090583, http://linkedlifedata.com/resource/pubmed/commentcorrection/17438272-16179466, http://linkedlifedata.com/resource/pubmed/commentcorrection/17438272-16863394, http://linkedlifedata.com/resource/pubmed/commentcorrection/17438272-1938947, http://linkedlifedata.com/resource/pubmed/commentcorrection/17438272-6170441, http://linkedlifedata.com/resource/pubmed/commentcorrection/17438272-9413994
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/7505876
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Luminescent Proteins
pubmed:status	MEDLINE
pubmed:month	Apr
pubmed:issn	0027-8424
pubmed:author	pubmed-author:AmdaoudMM, pubmed-author:MihalcescuII, pubmed-author:ValladeMM, pubmed-author:Weiss-SchaberCC
pubmed:issnType	Print
pubmed:day	24
pubmed:volume	104
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	7051-6
pubmed:dateRevised	2009-11-18
pubmed:meshHeading	pubmed-meshheading:17438272-Biological Clocks, pubmed-meshheading:17438272-Luminescent Proteins, pubmed-meshheading:17438272-Models, Biological, pubmed-meshheading:17438272-Synechococcus
pubmed:year	2007
pubmed:articleTitle	Cyanobacterial clock, a stable phase oscillator with negligible intercellular coupling.
pubmed:affiliation	Laboratoire de Spectrométrie Physique, Centre National de la Recherche Scientifique/Unité Mixte de Recherche 5588, Université Joseph Fourier-Grenoble I, BP 87, 38402 St. Martin d'Hères Cedex, France.
pubmed:publicationType	Journal Article, Research Support, Non-U.S. Gov't