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rdf:type |
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lifeskim:mentions |
umls-concept:C0003591,
umls-concept:C0007587,
umls-concept:C0016390,
umls-concept:C0021467,
umls-concept:C0021469,
umls-concept:C0024432,
umls-concept:C0026809,
umls-concept:C0032405,
umls-concept:C0033414,
umls-concept:C0205360,
umls-concept:C0271510,
umls-concept:C0332461,
umls-concept:C0392756,
umls-concept:C0456389,
umls-concept:C0521447,
umls-concept:C1280500,
umls-concept:C1518440,
umls-concept:C1521761,
umls-concept:C2936350
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pubmed:issue |
18
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pubmed:dateCreated |
2007-5-8
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pubmed:abstractText |
Poly(ADP-ribose) polymerase (PARP) was suggested to play a role in endothelial dysfunction that is associated with a number of cardiovascular diseases. We hypothesized that PARP may play an important role in atherogenesis and that its inhibition may attenuate atherosclerotic plaque development in an experimental model of atherosclerosis.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Apolipoproteins E,
http://linkedlifedata.com/resource/pubmed/chemical/Ccl2 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Chemokine CCL2,
http://linkedlifedata.com/resource/pubmed/chemical/Cholesterol,
http://linkedlifedata.com/resource/pubmed/chemical/Collagen,
http://linkedlifedata.com/resource/pubmed/chemical/Hydrogen Peroxide,
http://linkedlifedata.com/resource/pubmed/chemical/Isoquinolines,
http://linkedlifedata.com/resource/pubmed/chemical/Lipopolysaccharides,
http://linkedlifedata.com/resource/pubmed/chemical/NF-kappa B,
http://linkedlifedata.com/resource/pubmed/chemical/Poly(ADP-ribose) Polymerases,
http://linkedlifedata.com/resource/pubmed/chemical/Poly Adenosine Diphosphate Ribose,
http://linkedlifedata.com/resource/pubmed/chemical/Thiophenes,
http://linkedlifedata.com/resource/pubmed/chemical/Tissue Inhibitor of...,
http://linkedlifedata.com/resource/pubmed/chemical/Triglycerides,
http://linkedlifedata.com/resource/pubmed/chemical/thieno(2,3-c)isoquinolin-5-one
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1524-4539
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
8
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pubmed:volume |
115
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2442-50
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pubmed:dateRevised |
2007-12-3
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pubmed:meshHeading |
pubmed-meshheading:17438151-Active Transport, Cell Nucleus,
pubmed-meshheading:17438151-Animals,
pubmed-meshheading:17438151-Aortic Diseases,
pubmed-meshheading:17438151-Apolipoproteins E,
pubmed-meshheading:17438151-Apoptosis,
pubmed-meshheading:17438151-Atherosclerosis,
pubmed-meshheading:17438151-Cells, Cultured,
pubmed-meshheading:17438151-Chemokine CCL2,
pubmed-meshheading:17438151-Cholesterol,
pubmed-meshheading:17438151-Collagen,
pubmed-meshheading:17438151-Crosses, Genetic,
pubmed-meshheading:17438151-Diet, Atherogenic,
pubmed-meshheading:17438151-Drug Evaluation, Preclinical,
pubmed-meshheading:17438151-Foam Cells,
pubmed-meshheading:17438151-Gene Expression Regulation,
pubmed-meshheading:17438151-Genotype,
pubmed-meshheading:17438151-Hydrogen Peroxide,
pubmed-meshheading:17438151-Hypercholesterolemia,
pubmed-meshheading:17438151-Hypertriglyceridemia,
pubmed-meshheading:17438151-Isoquinolines,
pubmed-meshheading:17438151-Lipopolysaccharides,
pubmed-meshheading:17438151-Macrophages, Peritoneal,
pubmed-meshheading:17438151-Mice,
pubmed-meshheading:17438151-Mice, Inbred C57BL,
pubmed-meshheading:17438151-Mice, Knockout,
pubmed-meshheading:17438151-NF-kappa B,
pubmed-meshheading:17438151-Necrosis,
pubmed-meshheading:17438151-Oxidative Stress,
pubmed-meshheading:17438151-Poly(ADP-ribose) Polymerases,
pubmed-meshheading:17438151-Poly Adenosine Diphosphate Ribose,
pubmed-meshheading:17438151-Specific Pathogen-Free Organisms,
pubmed-meshheading:17438151-Thiophenes,
pubmed-meshheading:17438151-Tissue Inhibitor of Metalloproteinase-2,
pubmed-meshheading:17438151-Triglycerides
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pubmed:year |
2007
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pubmed:articleTitle |
Poly(ADP-ribose) polymerase inhibition reduces atherosclerotic plaque size and promotes factors of plaque stability in apolipoprotein E-deficient mice: effects on macrophage recruitment, nuclear factor-kappaB nuclear translocation, and foam cell death.
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pubmed:affiliation |
Louisiana State University Health Sciences Center, Department of Pharmacology, 1901 Perdido St, New Orleans, LA 70112, USA.
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pubmed:publicationType |
Journal Article
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