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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2007-4-17
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pubmed:abstractText |
An unexplained increase in the incidence of hypospadias has been reported, and yet to our knowledge the molecular events and their regulation leading to hypospadias remain unknown, although environmental compounds capable of endocrine activity are suspected. We screened on a global scale abnormalities in gene expression in human hypospadiac tissue compared to those in nonhypospadiac tissue. Additionally, microarray analysis of tissue from a pair of fraternal twins, including 1 with and 1 without hypospadias, served as a control for genetic variability. We hypothesized that gene expression would differ between hypospadiac vs nonhypospadiac tissue and fraternal twin data would show patterns similar to those of group data on hypospadiac and nonhypospadiac tissue.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/ATF3 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Activating Transcription Factor 3,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation,
http://linkedlifedata.com/resource/pubmed/chemical/CTGF protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/CYR61 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Connective Tissue Growth Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Cysteine-Rich Protein 61,
http://linkedlifedata.com/resource/pubmed/chemical/Estrogens,
http://linkedlifedata.com/resource/pubmed/chemical/GADD45B protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Immediate-Early Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Intercellular Signaling Peptides...,
http://linkedlifedata.com/resource/pubmed/chemical/RNA,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Estrogen
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0022-5347
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
177
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1939-46
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:17437852-Activating Transcription Factor 3,
pubmed-meshheading:17437852-Antigens, Differentiation,
pubmed-meshheading:17437852-Cluster Analysis,
pubmed-meshheading:17437852-Connective Tissue Growth Factor,
pubmed-meshheading:17437852-Cysteine-Rich Protein 61,
pubmed-meshheading:17437852-Estrogens,
pubmed-meshheading:17437852-Foreskin,
pubmed-meshheading:17437852-Genetic Predisposition to Disease,
pubmed-meshheading:17437852-Humans,
pubmed-meshheading:17437852-Hypospadias,
pubmed-meshheading:17437852-Immediate-Early Proteins,
pubmed-meshheading:17437852-Infant,
pubmed-meshheading:17437852-Intercellular Signaling Peptides and Proteins,
pubmed-meshheading:17437852-Male,
pubmed-meshheading:17437852-Microarray Analysis,
pubmed-meshheading:17437852-RNA,
pubmed-meshheading:17437852-Receptors, Estrogen,
pubmed-meshheading:17437852-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:17437852-Up-Regulation
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pubmed:year |
2007
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pubmed:articleTitle |
Up-regulation of estrogen responsive genes in hypospadias: microarray analysis.
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pubmed:affiliation |
Departments of Urology, Ninth People's Hospital, Shanghai Jiaotong University, Shanghai, People's Republic of China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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