Source:http://linkedlifedata.com/resource/pubmed/id/17437735
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
8
|
| pubmed:dateCreated |
2007-4-17
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| pubmed:abstractText |
In young patients, the accumulative burden of traditional cardiovascular risk factors may not be as significant as in an older population. Genetic risk factors were suggested to have a role in the early development of myocardial infarction (MI). However, data about the association between polymorphisms in heart disease-related genes and the early onset of a first MI are limited. In the present study, age at onset of a first MI was related to individual single-nucleotide polymorphisms in each of 18 prespecified candidate genes in a cohort of 814 patients enrolled in the Thrombogenic Factors and Recurrent Coronary Events (THROMBO) Study. Multivariate regression analysis showed in patients who had the high-risk genotypes of paraoxonase 1 (PON1) Q192R and endothelial nitric oxide synthase (eNOS) E298D that ages at onset of a first MI were 1.8 (p = 0.02) and 3.5 years (p = 0.02) earlier than in noncarriers of the genotypes, respectively. Consistently, high-risk genotypes of the PON1 Q192R and eNOS E298D polymorphisms were significantly associated with onset of a first MI at age <50 years (adjusted odds ratio 1.70, p = 0.005, adjusted odds ratio 2.15, p = 0.01, respectively). In conclusion, our findings suggest that high-risk genotypes of the PON1 Q192R and eNOS E298D polymorphisms are independently associated with a significantly earlier occurrence of coronary events.
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| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Arginine,
http://linkedlifedata.com/resource/pubmed/chemical/Aryldialkylphosphatase,
http://linkedlifedata.com/resource/pubmed/chemical/Aspartic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Glutamic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Glutamine,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide Synthase Type III,
http://linkedlifedata.com/resource/pubmed/chemical/PON1 protein, human
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| pubmed:status |
MEDLINE
|
| pubmed:month |
Apr
|
| pubmed:issn |
0002-9149
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
15
|
| pubmed:volume |
99
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1100-5
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| pubmed:dateRevised |
2007-12-3
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| pubmed:meshHeading |
pubmed-meshheading:17437735-Adult,
pubmed-meshheading:17437735-Age of Onset,
pubmed-meshheading:17437735-Aged,
pubmed-meshheading:17437735-Aged, 80 and over,
pubmed-meshheading:17437735-Arginine,
pubmed-meshheading:17437735-Aryldialkylphosphatase,
pubmed-meshheading:17437735-Aspartic Acid,
pubmed-meshheading:17437735-Cohort Studies,
pubmed-meshheading:17437735-Female,
pubmed-meshheading:17437735-Follow-Up Studies,
pubmed-meshheading:17437735-Genetic Predisposition to Disease,
pubmed-meshheading:17437735-Genotype,
pubmed-meshheading:17437735-Glutamic Acid,
pubmed-meshheading:17437735-Glutamine,
pubmed-meshheading:17437735-Humans,
pubmed-meshheading:17437735-Male,
pubmed-meshheading:17437735-Middle Aged,
pubmed-meshheading:17437735-Myocardial Infarction,
pubmed-meshheading:17437735-Nitric Oxide Synthase Type III,
pubmed-meshheading:17437735-Polymorphism, Single Nucleotide,
pubmed-meshheading:17437735-Prospective Studies,
pubmed-meshheading:17437735-Risk Factors
|
| pubmed:year |
2007
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| pubmed:articleTitle |
Polymorphisms in the paraoxonase and endothelial nitric oxide synthase genes and the risk of early-onset myocardial infarction.
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| pubmed:affiliation |
Cardiology Unit, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Multicenter Study,
Research Support, N.I.H., Extramural
|