Linked Life Data

17437722

Source:http://linkedlifedata.com/resource/pubmed/id/17437722

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
2007-4-17
pubmed:abstractText
Sirolimus-eluting stents (SESs) recently proved to be superior to bare metal stents (BMSs) in decreasing the need for repeat revascularization in patients with ST-segment elevation myocardial infarction (STEMI) at 1 year. Whether this also holds for paclitaxel-eluting stents (PESs) is currently unclear and the long-term relatively efficacy of the 2 drug-eluting stents is currently unknown. We investigated the 3-year efficacy of SESs and PESs versus BMSs in patients with STEMI. Primary angioplasty was performed in a consecutive group of 505 patients (BMSs in 183, SESs in 186, PESs in 136). At 3 years, the cumulative mortality rate was comparable in the 3 groups: 13.3% in the BMS group, 11.5% in the SES group, and 12.4% in the PES group (nonsignificant for all). The rate of target vessel revascularization (TVR) was 12.0% in the BMS group compared with 8.0% and 7.7% in the SES and PES groups, respectively (p = 0.12 for BMS vs SES, 0.30 for BMS vs PES, 0.62 for SES vs PES). The cumulative incidence of death, MI, or TVR was 25.5% in the BMS group compared with 17.9% and 20.6% in the SES and PES groups, respectively (p = 0.06 for BMS vs SES, 0.32 for BMS vs PES, 0.45 for SES vs PES). Angiographic stent thrombosis occurred in 2.4% of all patients (BMS 1.6%, SES 2.7%, PES 2.9%). In conclusion, in this relatively small consecutive patient cohort, the use of SESs and PESs was no longer associated with significantly lower rates of TVR and major adverse cardiace events in patients with STEMI after 3 years of follow-up. A high frequency of stent thrombosis was observed in the 2 drug-eluting stent groups.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0002-9149
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
99
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1027-32
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed-meshheading:17437722-Angioplasty, Balloon, Coronary, pubmed-meshheading:17437722-Cause of Death, pubmed-meshheading:17437722-Cohort Studies, pubmed-meshheading:17437722-Coronary Restenosis, pubmed-meshheading:17437722-Electrocardiography, pubmed-meshheading:17437722-Female, pubmed-meshheading:17437722-Fibrinolytic Agents, pubmed-meshheading:17437722-Follow-Up Studies, pubmed-meshheading:17437722-Humans, pubmed-meshheading:17437722-Male, pubmed-meshheading:17437722-Middle Aged, pubmed-meshheading:17437722-Myocardial Infarction, pubmed-meshheading:17437722-Paclitaxel, pubmed-meshheading:17437722-Platelet Aggregation Inhibitors, pubmed-meshheading:17437722-Prospective Studies, pubmed-meshheading:17437722-Recurrence, pubmed-meshheading:17437722-Registries, pubmed-meshheading:17437722-Retrospective Studies, pubmed-meshheading:17437722-Sirolimus, pubmed-meshheading:17437722-Stents, pubmed-meshheading:17437722-Survival Rate, pubmed-meshheading:17437722-Ticlopidine, pubmed-meshheading:17437722-Treatment Outcome
pubmed:year
2007
pubmed:articleTitle
Comparison of three-year clinical outcome of sirolimus- and paclitaxel-eluting stents versus bare metal stents in patients with ST-segment elevation myocardial infarction (from the RESEARCH and T-SEARCH Registries).
pubmed:affiliation
Thoraxcenter, Erasmus Medical Center, Rotterdam, The Netherlands.
pubmed:publicationType
Journal Article, Clinical Trial, Comparative Study