|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0001655,
umls-concept:C0021467,
umls-concept:C0021469,
umls-concept:C0030685,
umls-concept:C0037659,
umls-concept:C0037663,
umls-concept:C0391871,
umls-concept:C0680255,
umls-concept:C1283071,
umls-concept:C1963578,
umls-concept:C2249825
|
|
pubmed:issue |
2
|
|
pubmed:dateCreated |
1976-3-15
|
|
pubmed:abstractText |
The rapid injection of 0.5 or 1.0 mg of tetracosacitid (Synacthen¿) was followed by a distinct increase of plasma growth hormone (GH) within 30 or 45 min in 5 of 7 normal volunteers. A second control test was performed in 3 of the 5 "responders" and 1 "non-responder" and showed a consistent reaction in all of them. The tests were then repeated in the 5 "responders" during an infusion of somatostatin (150 mug/h) and the GH response was totally abolished (3 subjects) or markedly reduced (2 subjects). Thus the ACTH induced GH release behaves in a manner similar to most other physiological or pharmacological stimuli of GH release. The cortisol output after ACTH was not altered by somatostatin.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Feb
|
|
pubmed:issn |
0001-5598
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
81
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
263-9
|
|
pubmed:dateRevised |
2006-11-15
|
|
pubmed:meshHeading |
|
|
pubmed:year |
1976
|
|
pubmed:articleTitle |
The stimulation of growth hormone release by ACTH and its inhibition by somatostatin.
|
|
pubmed:publicationType |
Journal Article
|
