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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5826
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pubmed:dateCreated |
2007-5-14
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pubmed:abstractText |
Obesity is a serious international health problem that increases the risk of several common diseases. The genetic factors predisposing to obesity are poorly understood. A genome-wide search for type 2 diabetes-susceptibility genes identified a common variant in the FTO (fat mass and obesity associated) gene that predisposes to diabetes through an effect on body mass index (BMI). An additive association of the variant with BMI was replicated in 13 cohorts with 38,759 participants. The 16% of adults who are homozygous for the risk allele weighed about 3 kilograms more and had 1.67-fold increased odds of obesity when compared with those not inheriting a risk allele. This association was observed from age 7 years upward and reflects a specific increase in fat mass.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/17434869-11956760,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17434869-12508255,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17434869-12958120,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17434869-15096099,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17434869-16025115,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17434869-16595758,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17434869-16614226,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17434869-16731858,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17434869-16862161,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17434869-17065358,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17434869-7956835,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17434869-9519560
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1095-9203
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pubmed:author |
pubmed-author:BarrettJeffrey CJC,
pubmed-author:BarrosoInêsI,
pubmed-author:Ben-ShlomoYoavY,
pubmed-author:BennettAmanda JAJ,
pubmed-author:CardonLon RLR,
pubmed-author:DoneyAlex S FAS,
pubmed-author:EbrahimShahS,
pubmed-author:EllardSianS,
pubmed-author:ElliottKatherine SKS,
pubmed-author:FerrucciLuigiL,
pubmed-author:FraylingTimothy MTM,
pubmed-author:FreathyRachel MRM,
pubmed-author:GrovesChristopher JCJ,
pubmed-author:HarriesLorna WLW,
pubmed-author:HattersleyAndrew TAT,
pubmed-author:HitmanGraham AGA,
pubmed-author:JarvelinMarjo-RiittaMR,
pubmed-author:KarpeFredrikF,
pubmed-author:KnightBridgetB,
pubmed-author:LangoHanaH,
pubmed-author:LawlorDebbie ADA,
pubmed-author:LindgrenCecilia MCM,
pubmed-author:LoosRuth J FRJ,
pubmed-author:McCarthyMark IMI,
pubmed-author:MelzerDavidD,
pubmed-author:MorrisAndrew DAD,
pubmed-author:NessAndrew RAR,
pubmed-author:OwenKatharine RKR,
pubmed-author:PalmerColin N ACN,
pubmed-author:PatchAnn-MarieAM,
pubmed-author:PerryJohn R BJR,
pubmed-author:RaynerNigel WNW,
pubmed-author:RingSusan MSM,
pubmed-author:ShieldsBeverleyB,
pubmed-author:SmithGeorge DaveyGD,
pubmed-author:SovioUllaU,
pubmed-author:TimpsonNicholas JNJ,
pubmed-author:WalkerMarkM,
pubmed-author:WarehamNicholas JNJ,
pubmed-author:WeedonMichael NMN,
pubmed-author:ZegginiEleftheriaE
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pubmed:issnType |
Electronic
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pubmed:day |
11
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pubmed:volume |
316
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
889-94
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pubmed:dateRevised |
2011-9-19
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pubmed:meshHeading |
pubmed-meshheading:17434869-Humans,
pubmed-meshheading:17434869-Adolescent,
pubmed-meshheading:17434869-Aged,
pubmed-meshheading:17434869-Child,
pubmed-meshheading:17434869-Infant, Newborn,
pubmed-meshheading:17434869-Great Britain,
pubmed-meshheading:17434869-Obesity,
pubmed-meshheading:17434869-Female,
pubmed-meshheading:17434869-Male,
pubmed-meshheading:17434869-Adipose Tissue,
pubmed-meshheading:17434869-Adult,
pubmed-meshheading:17434869-Birth Weight,
pubmed-meshheading:17434869-Middle Aged,
pubmed-meshheading:17434869-Homozygote,
pubmed-meshheading:17434869-Case-Control Studies,
pubmed-meshheading:17434869-Alleles,
pubmed-meshheading:17434869-Genetic Predisposition to Disease,
pubmed-meshheading:17434869-Cohort Studies,
pubmed-meshheading:17434869-Body Mass Index
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