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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2007-6-11
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pubmed:abstractText |
This study was designed to investigate the roles of programmed death-1 (PD-1) and PD-1 ligands (PD-L) in the development of murine acute myocarditis caused by Coxsackievirus B3. PD-1/PD-L belong to the CD28/B7 superfamily, and the PD-1/PD-L pathway is known to transduce a negative immunoregulatory signal that antagonizes the T-cell receptor-CD28 signal and inhibits T-cell activation.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD274,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD80,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation,
http://linkedlifedata.com/resource/pubmed/chemical/Biological Markers,
http://linkedlifedata.com/resource/pubmed/chemical/CD40 Ligand,
http://linkedlifedata.com/resource/pubmed/chemical/Cd274 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Fas Ligand Protein,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-gamma,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-2,
http://linkedlifedata.com/resource/pubmed/chemical/Ligands,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/PD-1 antigen, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/PDCD1LG2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Pdcd1lg2 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Peptides,
http://linkedlifedata.com/resource/pubmed/chemical/Perforin,
http://linkedlifedata.com/resource/pubmed/chemical/Pore Forming Cytotoxic Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Programmed Cell Death 1 Ligand 2...,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0008-6363
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
75
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
158-67
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:17434153-Acute Disease,
pubmed-meshheading:17434153-Animals,
pubmed-meshheading:17434153-Antibodies, Monoclonal,
pubmed-meshheading:17434153-Antigen-Antibody Reactions,
pubmed-meshheading:17434153-Antigens, CD274,
pubmed-meshheading:17434153-Antigens, CD80,
pubmed-meshheading:17434153-Antigens, Differentiation,
pubmed-meshheading:17434153-Apoptosis,
pubmed-meshheading:17434153-Biological Markers,
pubmed-meshheading:17434153-CD40 Ligand,
pubmed-meshheading:17434153-Cells, Cultured,
pubmed-meshheading:17434153-Coxsackievirus Infections,
pubmed-meshheading:17434153-Enterovirus B, Human,
pubmed-meshheading:17434153-Fas Ligand Protein,
pubmed-meshheading:17434153-Female,
pubmed-meshheading:17434153-Immunohistochemistry,
pubmed-meshheading:17434153-Interferon-gamma,
pubmed-meshheading:17434153-Interleukin-2,
pubmed-meshheading:17434153-Ligands,
pubmed-meshheading:17434153-Lymphocyte Activation,
pubmed-meshheading:17434153-Male,
pubmed-meshheading:17434153-Membrane Glycoproteins,
pubmed-meshheading:17434153-Mice,
pubmed-meshheading:17434153-Mice, Inbred C3H,
pubmed-meshheading:17434153-Microscopy, Fluorescence,
pubmed-meshheading:17434153-Myocarditis,
pubmed-meshheading:17434153-Peptides,
pubmed-meshheading:17434153-Perforin,
pubmed-meshheading:17434153-Pore Forming Cytotoxic Proteins,
pubmed-meshheading:17434153-Programmed Cell Death 1 Ligand 2 Protein,
pubmed-meshheading:17434153-RNA, Messenger,
pubmed-meshheading:17434153-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:17434153-T-Lymphocytes
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pubmed:year |
2007
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pubmed:articleTitle |
Roles of programmed death-1 (PD-1)/PD-1 ligands pathway in the development of murine acute myocarditis caused by coxsackievirus B3.
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pubmed:affiliation |
Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Tokyo 113-8655, Japan. sekoyosh-tky@umin.ac.jp
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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