|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
3
|
|
pubmed:dateCreated |
2007-4-13
|
|
pubmed:abstractText |
An association between Epstein-Barr virus (EBV) infection and systemic lupus erythematosus (SLE) has been suggested from previous serologic evidence. Since most adults in Taiwan are EBV-infected, seroepidemiologic studies based on standard assays for EBV are unlikely to dissociate SLE patients and control groups. We reexamine this question by using novel methodologies in which IgA anti-EBV-coded nuclear antigens-1 (EBNA-1) and IgG anti-EBV DNase antibodies were analysed by ELISA, and EBV viral loads were detected by real-time quantitative PCR for 93 adult SLE patients and 370 age-, sex- and living place-matched healthy controls in Taiwan. The specificities of antibodies for extractible nuclear antigens were determined by Western blot. Our results show that IgA anti-EBV EBNA1 antibodies were detectable in 31.2% SLE patients but only in 4.1% of controls (odds ratio [OR] = 10.72, 95% confidence interval [CI] = 5.19-22.35; P < 10(-7)), IgG anti-EBV DNase antibodies were detected in 53.8% SLE patients but only in 12.2% controls (OR = 8.40, 95% CI = 4.87-14.51; P < 10(-7)). EBV DNA was amplifiable from the sera of 41.9% SLE patients but from only 3.24% controls (P < 0.05). A significant association of IgG anti-EBV DNase antibodies with anti-Sm/RNP antibodies was observed (P < 0.005). The higher seroreactivity and higher copy numbers of EBV genome indicated association of EBV infection with SLE in Taiwan.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adrenal Cortex Hormones,
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Viral,
http://linkedlifedata.com/resource/pubmed/chemical/Autoantigens,
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Viral,
http://linkedlifedata.com/resource/pubmed/chemical/Deoxyribonucleases,
http://linkedlifedata.com/resource/pubmed/chemical/EBV-encoded nuclear antigen 1,
http://linkedlifedata.com/resource/pubmed/chemical/Epstein-Barr Virus Nuclear Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin A,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin G,
http://linkedlifedata.com/resource/pubmed/chemical/Ribonucleoproteins, Small Nuclear,
http://linkedlifedata.com/resource/pubmed/chemical/snRNP Core Proteins
|
|
pubmed:status |
MEDLINE
|
|
pubmed:issn |
0961-2033
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
16
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
168-75
|
|
pubmed:dateRevised |
2008-11-21
|
|
pubmed:meshHeading |
pubmed-meshheading:17432101-Adrenal Cortex Hormones,
pubmed-meshheading:17432101-Adult,
pubmed-meshheading:17432101-Antibodies, Viral,
pubmed-meshheading:17432101-Asian Continental Ancestry Group,
pubmed-meshheading:17432101-Autoantigens,
pubmed-meshheading:17432101-DNA, Viral,
pubmed-meshheading:17432101-Deoxyribonucleases,
pubmed-meshheading:17432101-Dose-Response Relationship, Drug,
pubmed-meshheading:17432101-Epstein-Barr Virus Infections,
pubmed-meshheading:17432101-Epstein-Barr Virus Nuclear Antigens,
pubmed-meshheading:17432101-Genome, Viral,
pubmed-meshheading:17432101-Herpesvirus 4, Human,
pubmed-meshheading:17432101-Humans,
pubmed-meshheading:17432101-Immunoglobulin A,
pubmed-meshheading:17432101-Immunoglobulin G,
pubmed-meshheading:17432101-Lupus Erythematosus, Systemic,
pubmed-meshheading:17432101-Middle Aged,
pubmed-meshheading:17432101-Ribonucleoproteins, Small Nuclear,
pubmed-meshheading:17432101-Taiwan,
pubmed-meshheading:17432101-Viral Load,
pubmed-meshheading:17432101-snRNP Core Proteins
|
|
pubmed:year |
2007
|
|
pubmed:articleTitle |
Association of Epstein-Barr virus infection with systemic lupus erythematosus in Taiwan.
|
|
pubmed:affiliation |
National Taichung Nursing College, Taichung, Taiwan.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
