17431797

Source:http://linkedlifedata.com/resource/pubmed/id/17431797

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C1522240, umls-concept:C2262789
pubmed:issue	1
pubmed:dateCreated	2007-4-13
pubmed:abstractText	Mammary gland involution is a highly complex multi-step process in which the lactating gland returns to a morphologically near pre-pregnant state. This developmental stage is characterized by a high degree of epithelial cell death, redevelopment of the mammary adipose tissue and tissue remodelling. Many factors involved have been described and these have been reviewed intensively in this journal (Furth, P. A., J. Mammary Gland Biol. Neoplasia, 4:123-127, 1999) and elsewhere. Microarray analysis technology has now not only allowed us to identify genes not previously associated with involution (Stein, T., Morris, J.S., Davis, C.R.,Weber-Hall, S.J., Duffy, M.A., Heath, V.J., et al., Breast Cancer Res., 6: R75-R91, 2004; Clarkson, R.W., Wayland, M.T., Lee, J., Freeman, T., Watson, C.J., Breast Cancer Res., 6: R92-R109, 2004; Clarkson, R.W., Watson, C.J., J. Mammary Gland Biol. Neoplasia, 8: 309-319, 2003), it has also enabled us to define multiple phases of the controlled regulatory response to forced weaning on the basis of their transcriptional profiles. This review provides a synthesis of published data, integrating the time course of transcriptional activity in the mouse mammary gland with a gene ontology approach to identify the pathways involved.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/9601804
pubmed:citationSubset	IM
pubmed:status	MEDLINE
pubmed:month	Mar
pubmed:issn	1083-3021
pubmed:author	pubmed-author:GustersonBarry ABA, pubmed-author:SalomonisNathanN, pubmed-author:SteinTorstenT
pubmed:issnType	Print
pubmed:volume	12
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	25-35
pubmed:meshHeading	pubmed-meshheading:17431797-Animals, pubmed-meshheading:17431797-Female, pubmed-meshheading:17431797-Lactation, pubmed-meshheading:17431797-Mammary Glands, Animal, pubmed-meshheading:17431797-Mice, pubmed-meshheading:17431797-Milk, pubmed-meshheading:17431797-Weaning
pubmed:year	2007
pubmed:articleTitle	Mammary gland involution as a multi-step process.
pubmed:affiliation	Division of Cancer Sciences and Molecular Pathology, Section of Gene Regulation and Mechanisms of Disease, Western Infirmary, University of Glasgow, Glasgow G11 6NT, UK.
pubmed:publicationType	Journal Article, Review, Research Support, Non-U.S. Gov't