Linked Life Data

17431780

Source:http://linkedlifedata.com/resource/pubmed/id/17431780

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
2007-8-9
pubmed:abstractText
Although various types of artificial liver support systems (ALSSs) including a hybrid type have been made, few are practical ALSSs for treatment of acute and/or chronic hepatic failure. Titanium oxide (TiO(2)), a stable material, dismantles various materials using a photocatalytic action under ultraviolet irradiation. The aim of this study was to assess the effect of a new ALSS using TiO(2). Hepatic failure plasma obtained from patients undergoing plasma exchange therapy due to acute liver failure was used in these experiments. The plasma was perfused using a closed circuit model with a column filled with TiO(2). The plasma concentrations of total bilirubin, albumin, fibrinogen, interleukin (IL)-6, IL-8, and IL-10 were serially measured. We evaluated the photocatalytic effect of TiO(2) irradiated with ultraviolet light. The effect of initial perfusion with fresh-frozen plasma (FFP) was also investigated, focusing on the decrease in fibrinogen during perfusion. Levels of total bilirubin decreased after perfusion using the column filled with TiO(2), compared with no UV irradiation. The levels of IL-6, IL-8, and IL-10 decreased after perfusion using the TiO(2) device. The albumin level was maintained at the initial level, however, the fibrinogen level decreased within 4 hr. Initial perfusion of the circuit with FFP improved the decrease in fibrinogen for up to 8 hr. Our new perfusion device using the photocatalytic action of TiO(2) may be a promising ALSS.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0163-2116
pubmed:author
pubmed:issnType
Print
pubmed:volume
52
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2271-5
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
New type of artificial liver support system (ALSS) using the photocatalytic effect of titanium oxide.
pubmed:affiliation
Department of Digestive and Pediatric Surgery, Institute of Health Biosciences, The University of Tokushima Graduate School, 3-18-15 Kuramoto-cho, Tokushima City, Tokushima 770-8503, Japan.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't