Linked Life Data

17431704

Source:http://linkedlifedata.com/resource/pubmed/id/17431704

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
2007-8-6
pubmed:abstractText
Given the known roles of TGFbeta2 in both regulating the immune system and promoting the survival of dopaminergic neurons, it is feasible that genetic variations in TGFB2 might play an aetiological role in neurological diseases such as Multiple Sclerosis (MS) and Parkinson's disease (PD). Hence we performed an indirect association analysis of TGFB2 using 8 haplotype-tagging SNPs in a population of 937 MS patients, 538 PD cases and 2022 controls. We found no evidence for association with susceptibility or progression of MS, but have demonstrated a trend towards association of the 5' region of the gene with susceptibility to PD. Further analysis of TGFB2 is warranted in other PD cohorts.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0340-5354
pubmed:author
pubmed:issnType
Print
pubmed:volume
254
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
846-8
pubmed:dateRevised
2011-11-3
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Investigation of TGFB2 as a candidate gene in multiple sclerosis and Parkinson's disease.
pubmed:affiliation
Neurology Unit, Department of Clinical Neurosciences University of Cambridge, UK.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't