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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2007-7-24
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pubmed:abstractText |
We present a case of a 23-year-old man with a tumor containing glial and rhabdoid elements where the former had features of a pleomorphic xanthoastrocytoma (PXA) and the latter had the immunophenotype and genetic profile of an atypical rhabdoid/teratoid tumor. The patient presented with a short history of raised intracranial pressure with rapid deterioration in sensorium. He had a poor outcome despite surgery and radiotherapy. We report this case because of its unusual presentation in adulthood and its occurrence in association with a PXA. We speculate that the PXA was a quiescent tumor and that the secondary genetic alterations, including inactivation of the INI1 gene led to clinical progression.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0167-594X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
84
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
217-22
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pubmed:meshHeading |
pubmed-meshheading:17431546-Adult,
pubmed-meshheading:17431546-Astrocytoma,
pubmed-meshheading:17431546-Brain Neoplasms,
pubmed-meshheading:17431546-Chromosomal Proteins, Non-Histone,
pubmed-meshheading:17431546-Chromosomes, Human, Pair 22,
pubmed-meshheading:17431546-DNA Mutational Analysis,
pubmed-meshheading:17431546-DNA-Binding Proteins,
pubmed-meshheading:17431546-Fatal Outcome,
pubmed-meshheading:17431546-Humans,
pubmed-meshheading:17431546-Immunohistochemistry,
pubmed-meshheading:17431546-Magnetic Resonance Imaging,
pubmed-meshheading:17431546-Male,
pubmed-meshheading:17431546-Neoplasms, Multiple Primary,
pubmed-meshheading:17431546-Point Mutation,
pubmed-meshheading:17431546-Rhabdoid Tumor,
pubmed-meshheading:17431546-Teratoma,
pubmed-meshheading:17431546-Transcription Factors
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pubmed:year |
2007
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pubmed:articleTitle |
Atypical teratoid/rhabdoid tumor arising in the setting of a pleomorphic xanthoastrocytoma.
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pubmed:affiliation |
Division of Neuropathology, Department of Neurological Sciences, Christian Medical College, Vellore, India.
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pubmed:publicationType |
Journal Article,
Case Reports
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