Linked Life Data

17430084

Source:http://linkedlifedata.com/resource/pubmed/id/17430084

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2007-8-9
pubmed:abstractText
The observation that cycles of sleep and wakefulness occur with a periodicity fixed in time to match the rotation of the Earth on its axis provided a key to unlock the first genetic code for a neurobehavioral pathway in flies and ultimately in mice. As a remarkable outcome of this discovery, we have gained an unprecedented view of the conserved genetic program that encodes a sense of time across all kingdoms of life. The tools are now in hand to begin to understand how important processes such as energy homeostasis and fuel utilization are coordinated to anticipate daily changes in environment caused by the rising and setting of the sun. A better understanding of the impact of circadian gene networks on nutrient balance at the molecular, cellular, and system levels promises to shed light on the emerging association between disorders of diabetes, obesity, sleep, and circadian timing.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
0199-9885
pubmed:author
pubmed:issnType
Print
pubmed:volume
27
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
219-40
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
The clockwork of metabolism.
pubmed:affiliation
Department of Medicine, Feinberg School of Medicine, Northwestern University, Evanston, IL 60208, USA.
pubmed:publicationType
Journal Article, Review, Research Support, N.I.H., Extramural