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rdf:type |
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lifeskim:mentions |
umls-concept:C0003320,
umls-concept:C0017355,
umls-concept:C0026882,
umls-concept:C0039195,
umls-concept:C0085358,
umls-concept:C0205147,
umls-concept:C1167622,
umls-concept:C1332717,
umls-concept:C1413244,
umls-concept:C1706438,
umls-concept:C2349975,
umls-concept:C2698600
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pubmed:issue |
5
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pubmed:dateCreated |
2007-4-25
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pubmed:abstractText |
CD8(+) cytotoxic T lymphocytes (CTL) are key determinants of immunity to intracellular pathogens and neoplastic cells. Recognition of specific antigens in the form of peptide-MHC class I complexes (pMHCI) presented on the target cell surface is mediated by T cell receptor (TCR) engagement. The CD8 coreceptor binds to invariant domains of pMHCI and facilitates antigen recognition. Here, we investigate the biological effects of a Q115E substitution in the alpha2 domain of human leukocyte antigen (HLA)-A*0201 that enhances CD8 binding by approximately 50% without altering TCR/pMHCI interactions. Soluble and cell surface-expressed forms of Q115E HLA-A*0201 exhibit enhanced recognition by CTL without loss of specificity. These CD8-enhanced antigens induce greater CD3 zeta chain phosphorylation in cognate CTL leading to substantial increases in cytokine production, proliferation and priming of naive T cells. This effect provides a fundamental new mechanism with which to enhance cellular immunity to specific T cell antigens.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/17429845-10809759,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17429845-11371361,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17429845-11438524,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17429845-11466333,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17429845-11714755,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17429845-11729321,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17429845-11790535,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17429845-11854361,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17429845-11970876,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17429845-12001997,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17429845-12133804,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17429845-12215456,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17429845-12407102,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17429845-12432573,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17429845-12594952,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17429845-12615890,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17429845-12697765,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17429845-14662868,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17429845-15048111,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17429845-15664164,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17429845-15837791,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17429845-15980174,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17429845-16287711,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17429845-17273992,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17429845-2462676,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17429845-2477484,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17429845-3262426,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17429845-7830771,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17429845-8758894,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17429845-8810254,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17429845-9016871,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17429845-9177355,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17429845-9324358,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17429845-9341776,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17429845-9388235,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17429845-9512422,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17429845-9523116,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17429845-9539771,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17429845-9550407,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17429845-9597140,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17429845-9677202,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17429845-9806632,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17429845-9881972,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17429845-9916707,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17429845-9973498
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0014-2980
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pubmed:author |
pubmed-author:BoulterJonathan MJM,
pubmed-author:CerundoloVincenzoV,
pubmed-author:DunbarP RodPR,
pubmed-author:GlickMeirM,
pubmed-author:GostickEmmaE,
pubmed-author:HutchinsonSarah LSL,
pubmed-author:LaugelBrunoB,
pubmed-author:LissinaAnnaA,
pubmed-author:MirzaFareedF,
pubmed-author:PriceDavid ADA,
pubmed-author:SewellAndrew KAK,
pubmed-author:VernazzaJonathanJ,
pubmed-author:WooldridgeLindaL,
pubmed-author:van den BergHugo AHA
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pubmed:issnType |
Print
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pubmed:volume |
37
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pubmed:owner |
NLM
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|
pubmed:authorsComplete |
Y
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pubmed:pagination |
1323-33
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
|
