|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0013216,
umls-concept:C0027947,
umls-concept:C0030705,
umls-concept:C0085187,
umls-concept:C0087111,
umls-concept:C0205170,
umls-concept:C0439793,
umls-concept:C0871261,
umls-concept:C1444754,
umls-concept:C1704632,
umls-concept:C1706817,
umls-concept:C1707520,
umls-concept:C2243049,
umls-concept:C2911692
|
|
pubmed:issue |
1
|
|
pubmed:dateCreated |
2007-6-28
|
|
pubmed:abstractText |
This study evaluated the telomere length changes (DeltaTL) of peripheral blood mononuclear cells before and after repetitive standard-dose nonmyeloablative chemotherapy and the association of DeltaTL with treatment response and myelosuppression severity. TL was measured with Southern blot analysis in 32 solid-cancer patients without bone marrow metastasis. The mean TL before chemotherapy (t0 TL) and after the 2nd (t1 TL), 4th (t2 TL) and 6th cycle (t3 TL) was 8.49, 8.33, 8.08 and 8.10 kb, respectively. TL became significantly decreased after 4 (p = 0.005) and 6 (p = 0.026) cycles of chemotherapy. The mean value of DeltaTL before and after completion of chemotherapy (t0 TL - t3 TL) was 0.46 kb. DeltaTL has a significant correlation with good treatment response (r = 0.448, p = 0.005) and the frequency of severe neutropenia (r = 0.417, p < 0.05). Consequently, TL of peripheral blood mononuclear cells was decreased by the repetitive nonmyeloablative standard-dose chemotherapy in solid-cancer patients without bone marrow metastasis, and DeltaTL was associated with good treatment response and neutropenia severity.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:issn |
1421-9662
|
|
pubmed:author |
pubmed-author:ChoiChul WonCW,
pubmed-author:ChoiIn KeunIK,
pubmed-author:KimByung SooBS,
pubmed-author:KimJun SukJS,
pubmed-author:KimSeok JinSJ,
pubmed-author:KimYeul HongYH,
pubmed-author:OhSang CheulSC,
pubmed-author:ParkKyong HwaKH,
pubmed-author:SeoJae HongJH,
pubmed-author:ShinSang WonSW,
pubmed-author:SungHwa JungHJ,
pubmed-author:YoonSo YoungSY
|
|
pubmed:copyrightInfo |
Copyright 2007 S. Karger AG, Basel.
|
|
pubmed:issnType |
Electronic
|
|
pubmed:volume |
118
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
30-7
|
|
pubmed:meshHeading |
pubmed-meshheading:17429195-Aged,
pubmed-meshheading:17429195-Aged, 80 and over,
pubmed-meshheading:17429195-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:17429195-Cohort Studies,
pubmed-meshheading:17429195-Comorbidity,
pubmed-meshheading:17429195-Dose-Response Relationship, Drug,
pubmed-meshheading:17429195-Drug Administration Schedule,
pubmed-meshheading:17429195-Female,
pubmed-meshheading:17429195-Follow-Up Studies,
pubmed-meshheading:17429195-Humans,
pubmed-meshheading:17429195-Leukocytes, Mononuclear,
pubmed-meshheading:17429195-Male,
pubmed-meshheading:17429195-Neoplasms,
pubmed-meshheading:17429195-Neutropenia,
pubmed-meshheading:17429195-Probability,
pubmed-meshheading:17429195-Prospective Studies,
pubmed-meshheading:17429195-Risk Factors,
pubmed-meshheading:17429195-Sensitivity and Specificity,
pubmed-meshheading:17429195-Survival Analysis,
pubmed-meshheading:17429195-Telomerase,
pubmed-meshheading:17429195-Telomere,
pubmed-meshheading:17429195-Treatment Outcome,
pubmed-meshheading:17429195-Tumor Markers, Biological
|
|
pubmed:year |
2007
|
|
pubmed:articleTitle |
Telomere length shortening of peripheral blood mononuclear cells in solid-cancer patients undergoing standard-dose chemotherapy might be correlated with good treatment response and neutropenia severity.
|
|
pubmed:affiliation |
Department of Internal Medicine, Konkuk University Hospital, Seoul, Korea.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
