17429083

Source:http://linkedlifedata.com/resource/pubmed/id/17429083

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0011860, umls-concept:C0231491
pubmed:issue	15
pubmed:dateCreated	2007-4-12
pubmed:databankReference	http://linkedlifedata.com/resource/pubmed/xref/ClinicalTrials.gov/NCT00303394
pubmed:abstractText	The expression of interleukin-1-receptor antagonist is reduced in pancreatic islets of patients with type 2 diabetes mellitus, and high glucose concentrations induce the production of interleukin-1beta in human pancreatic beta cells, leading to impaired insulin secretion, decreased cell proliferation, and apoptosis.
pubmed:commentsCorrections	http://linkedlifedata.com/resource/pubmed/commentcorrection/17429083-17429082, http://linkedlifedata.com/resource/pubmed/commentcorrection/17429083-17634469, http://linkedlifedata.com/resource/pubmed/commentcorrection/17429083-17876346, http://linkedlifedata.com/resource/pubmed/commentcorrection/17429083-18031661, http://linkedlifedata.com/resource/pubmed/commentcorrection/17429083-18445348
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/0255562
pubmed:citationSubset	AIM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Blood Glucose, http://linkedlifedata.com/resource/pubmed/chemical/C-Reactive Protein, http://linkedlifedata.com/resource/pubmed/chemical/Glucose Transporter Type 4, http://linkedlifedata.com/resource/pubmed/chemical/Heat-Shock Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Hemoglobin A, Glycosylated, http://linkedlifedata.com/resource/pubmed/chemical/Interleukin 1 Receptor Antagonist..., http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-6, http://linkedlifedata.com/resource/pubmed/chemical/PPARGC1A protein, human, http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger, http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Interleukin-1, http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors
pubmed:status	MEDLINE
pubmed:month	Apr
pubmed:issn	1533-4406
pubmed:author	pubmed-author:DonathMarc YMY, pubmed-author:EhsesJan AJA, pubmed-author:FaulenbachMirjamM, pubmed-author:LarsenClaus MCM, pubmed-author:Mandrup-PoulsenThomasT, pubmed-author:SeifertBurkhardtB, pubmed-author:VølundAageA, pubmed-author:VaagAllanA
pubmed:copyrightInfo	Copyright 2007 Massachusetts Medical Society.
pubmed:issnType	Electronic
pubmed:day	12
pubmed:volume	356
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	1517-26
pubmed:dateRevised	2008-6-10
pubmed:meshHeading	pubmed-meshheading:17429083-Blood Glucose, pubmed-meshheading:17429083-Body Mass Index, pubmed-meshheading:17429083-C-Reactive Protein, pubmed-meshheading:17429083-Diabetes Mellitus, Type 2, pubmed-meshheading:17429083-Double-Blind Method, pubmed-meshheading:17429083-Female, pubmed-meshheading:17429083-Gene Expression Regulation, pubmed-meshheading:17429083-Glucose Tolerance Test, pubmed-meshheading:17429083-Glucose Transporter Type 4, pubmed-meshheading:17429083-Heat-Shock Proteins, pubmed-meshheading:17429083-Hemoglobin A, Glycosylated, pubmed-meshheading:17429083-Humans, pubmed-meshheading:17429083-Insulin Resistance, pubmed-meshheading:17429083-Insulin-Secreting Cells, pubmed-meshheading:17429083-Interleukin 1 Receptor Antagonist Protein, pubmed-meshheading:17429083-Interleukin-6, pubmed-meshheading:17429083-Male, pubmed-meshheading:17429083-Middle Aged, pubmed-meshheading:17429083-RNA, Messenger, pubmed-meshheading:17429083-Receptors, Interleukin-1, pubmed-meshheading:17429083-Recombinant Proteins, pubmed-meshheading:17429083-Transcription Factors
pubmed:year	2007
pubmed:articleTitle	Interleukin-1-receptor antagonist in type 2 diabetes mellitus.
pubmed:affiliation	Steno Diabetes Center, Gentofte, Denmark.
pubmed:publicationType	Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't, Multicenter Study