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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2007-4-24
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pubmed:abstractText |
Streptococcus (S.) pneumoniae meningitis has a high lethality despite antibiotic treatment. Inflammation is a major pathogenetic factor, which is unresponsive to antibiotics. Therefore adjunctive therapies with antiinflammatory compounds have been developed. TNF484 is a TNF-alpha converting enzyme (TACE) inhibitor and has been found efficacious in experimental meningitis. Toll-like receptor 2 (TLR2) contributes to host response in pneumococcal meningitis by enhancing bacterial clearing and downmodulating inflammation. In this study, TNF484 was applied in mice, which lacked TLR2 and exhibited a strong meningeal inflammation.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/17428319-10202018,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17428319-10364168,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17428319-10426995,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17428319-10639424,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17428319-11023483,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17428319-11484822,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17428319-11502220,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17428319-11522576,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17428319-11728765,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17428319-11781269,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17428319-11870620,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17428319-12014967,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17428319-12015459,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17428319-12196527,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17428319-12198614,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17428319-12424702,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17428319-12467688,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17428319-12496429,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17428319-12788989,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17428319-14513425,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17428319-15143282,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17428319-15145598,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17428319-15578971,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17428319-15714590,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17428319-15941778,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17428319-16137770,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17428319-16164030,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17428319-16226506,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17428319-16299338,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17428319-9395430,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17428319-9535844
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/ADAM Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Anti-Bacterial Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD14,
http://linkedlifedata.com/resource/pubmed/chemical/Ceftriaxone,
http://linkedlifedata.com/resource/pubmed/chemical/Hydroxamic Acids,
http://linkedlifedata.com/resource/pubmed/chemical/N(4)-(2,2-dimethyl-1-methylcarbamoyl...,
http://linkedlifedata.com/resource/pubmed/chemical/Tlr2 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Toll-Like Receptor 2,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha,
http://linkedlifedata.com/resource/pubmed/chemical/tumor necrosis factor-alpha...
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pubmed:status |
MEDLINE
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pubmed:issn |
1471-2334
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
7
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
25
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:17428319-ADAM Proteins,
pubmed-meshheading:17428319-Animals,
pubmed-meshheading:17428319-Anti-Bacterial Agents,
pubmed-meshheading:17428319-Antigens, CD14,
pubmed-meshheading:17428319-Ceftriaxone,
pubmed-meshheading:17428319-Chemotherapy, Adjuvant,
pubmed-meshheading:17428319-Female,
pubmed-meshheading:17428319-Hydroxamic Acids,
pubmed-meshheading:17428319-Male,
pubmed-meshheading:17428319-Meningitis, Pneumococcal,
pubmed-meshheading:17428319-Mice,
pubmed-meshheading:17428319-Mice, Inbred C57BL,
pubmed-meshheading:17428319-Mice, Knockout,
pubmed-meshheading:17428319-Pneumococcal Infections,
pubmed-meshheading:17428319-Streptococcus pneumoniae,
pubmed-meshheading:17428319-Toll-Like Receptor 2,
pubmed-meshheading:17428319-Tumor Necrosis Factor-alpha
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pubmed:year |
2007
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pubmed:articleTitle |
Adjuvant TACE inhibitor treatment improves the outcome of TLR2-/- mice with experimental pneumococcal meningitis.
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pubmed:affiliation |
Division of Infectious Diseases, Department of Research, University Hospitals, Basel, Switzerland. Hakim.echchannaoui@unibas.ch <Hakim.echchannaoui@unibas.ch>
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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