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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2007-4-11
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pubmed:abstractText |
In Alzheimer's disease (AD), beta-amyloid (Abeta) plaques are surrounded by activated astrocytes and microglia. A growing body of evidence suggests that these activated astrocytes contribute to neurotoxicity through the induction of inflammatory cytokines and the production of oxidative stress mediators. Thus, a compound inhibiting Abeta-induced activation of astrocytes may lead to a novel therapy for AD. Our current work investigates the roles of acidic oligosaccharide sugar chain (AOSC), derived from brown algae Echlonia Kurome Okam, on Abeta-induced inflammatory responses and cytotoxicity. We observed that AOSC inhibited the toxicity and apoptosis in SH-SY5Y cell line induced by Abeta-stimulated astrocytes conditioned medium. We found that AOSC inhibited the reactive phenotype of astrocytes, blocked cellular oxidative stress, reduced the production of tumor necrosis factor (TNF)-alpha and interleukin (IL)-6 and prevented the influx of Ca2+. Thus, our results indicate that AOSC might be a potentially therapeutic compound for AD.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0161-6412
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
29
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
96-102
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:17427283-Alzheimer Disease,
pubmed-meshheading:17427283-Amyloid beta-Peptides,
pubmed-meshheading:17427283-Animals,
pubmed-meshheading:17427283-Animals, Newborn,
pubmed-meshheading:17427283-Astrocytes,
pubmed-meshheading:17427283-Calcium Signaling,
pubmed-meshheading:17427283-Cells, Cultured,
pubmed-meshheading:17427283-Culture Media, Conditioned,
pubmed-meshheading:17427283-Cytokines,
pubmed-meshheading:17427283-Encephalitis,
pubmed-meshheading:17427283-Gliosis,
pubmed-meshheading:17427283-Interleukin-6,
pubmed-meshheading:17427283-Mannans,
pubmed-meshheading:17427283-Nerve Degeneration,
pubmed-meshheading:17427283-Oxidative Stress,
pubmed-meshheading:17427283-Rats,
pubmed-meshheading:17427283-Rats, Wistar,
pubmed-meshheading:17427283-Tumor Necrosis Factor-alpha
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pubmed:year |
2007
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pubmed:articleTitle |
A marine-derived acidic oligosaccharide sugar chain specifically inhibits neuronal cell injury mediated by beta-amyloid-induced astrocyte activation in vitro.
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pubmed:affiliation |
Department of Pharmacology, Marine Drug and Food Institute, Ocean University of China, Qingdao 266003, China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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