Our objective was to demonstrate that the smaller oxoreductase activity of 11beta-HSD1 in women would shift the interconversion of cortisol and cortisone toward cortisone, resulting in a larger amount of generated labeled cortisone in healthy women than in healthy men.
Clinical Division of Endocrinology and Metabolism, Department of Internal Medicine III, Währinger Gürtel 18-20, A-1090 Wien, Austria. heinrich.vierhapper@meduniwien.ac.at
