Linked Life Data

1742615

Source:http://linkedlifedata.com/resource/pubmed/id/1742615

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1992-1-13
pubmed:abstractText
Androgens have been linked to asymmetric brain development. Our results show that in sexually active male gerbils, the volume of the sexually dimorphic area, pars compacta (SDApc) of the preoptic region was positively correlated with the emission rate of an ultrasonic courtship vocalization. Day 1 postnatal treatment of female gerbils with testosterone propionate (TP, 100 micrograms, n = 16) or diethylstilbestrol (DES, 5 micrograms, n = 22) followed by ovariectomy and implantation of testosterone (T) filled silastic capsules in adulthood (day 120-130), increased mean volumes of the SDApc (TP, 1.21: DES, 0.84 mm3 x 10(-3)) and a second sexually dimorphic nucleus, the suprachiasmatic nucleus (SCN) (TP, 295: DES, 287.7 mm3 x 10(-3] compared to control females (n = 13) also given T in adulthood (SDApc = 0.37, SCN = 197.0 mm3 x 10(-3)). Rates of sexually dimorphic ultrasonic calls emitted during sexual interactions with estrous females (TP, 39.3: DES, 28.1 per min) were also increased relative to female controls (22.5 per min). With both treatments, significant covariances were revealed between vocalization rates and the left SDApc volumes [TP (rho), rho = .74: DES, rho = .43], but not the contralateral nucleus. Asymmetric development was absent in control females which received T as adults. Lateralization was specific to the SDApc, since no relationship was seen between either rates of calling and SCN volumes, or frequencies of nonvocal sexual components and the volumes of the SDApc or SCN. We conclude that steroid sex hormones influence lateralization of brain structure related to vocal behavior. The hormonal effect, which is likely to involve estrogen, occurs during neonatal development.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0361-9230
pubmed:author
pubmed:issnType
Print
pubmed:volume
27
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
261-5
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1991
pubmed:articleTitle
Lateralized action of androgen on development of behavior and brain sex differences.
pubmed:affiliation
MRC Neuroendocrine Development and Behaviour Group, Institute of Animal Physiology and Genetics Research, Babraham, Cambridge, UK.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't