Source:http://linkedlifedata.com/resource/pubmed/id/17425742
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
2007-4-11
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| pubmed:abstractText |
Between December 2000 and December 2005, 25 isolated intestinal transplants from cadaveric donors have been performed for short gut syndrome (short bowel syndrome, 52%), chronic intestinal pseudo-obstruction (24%), Gardner syndrome (16%), radiation enteritis (4%) and massive intestinal angiomatosis (4%). Indications for transplantation were: loss of venous access, recurrent sepsis due to central line infection, major electrolyte and fluid imbalance. Liver dysfunction was present in 13 cases. All patients were adult; median age was 36.3 yr and mean weight at transplantation 61.6 kg. All recipients were on life-threatening parenteral nutrition for a mean time of 23.7 months. Mean donor/recipient body weight ratio was 1.08. Rejection monitoring was accomplished by graft ileoendoscopies and intestinal biopsies through the temporary ileostomy. Our immunosuppressive regimen was based on induction therapy with three different protocols: daclizumab for induction, tacrolimus and steroids as maintenance therapy; alemtuzumab for induction and low-dose tacrolimus as maintenance; thymoglobulin for induction and maintenance based on low-dose tacrolimus. Closure of the abdomen at the end of transplantation represented a technical problem with several options performed: graft reduction, only skin closure, prothesic meshes, abdominal closure in two steps, cutaneous flaps and abdominal wall transplant in one case.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0902-0063
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| pubmed:author |
pubmed-author:AmaduzziAA,
pubmed-author:CesconMM,
pubmed-author:DazziAA,
pubmed-author:Del GaudioMM,
pubmed-author:ErcolaniGG,
pubmed-author:GolfieriLL,
pubmed-author:GraziG LGL,
pubmed-author:LauroAA,
pubmed-author:PinnaA DAD,
pubmed-author:PirontAA,
pubmed-author:RavaioliMM,
pubmed-author:VarottoAA,
pubmed-author:VivarelliMM,
pubmed-author:ZanfiCC
|
| pubmed:issnType |
Print
|
| pubmed:volume |
21
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
177-85
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| pubmed:meshHeading |
pubmed-meshheading:17425742-Adolescent,
pubmed-meshheading:17425742-Adult,
pubmed-meshheading:17425742-Colostomy,
pubmed-meshheading:17425742-Enteritis,
pubmed-meshheading:17425742-Female,
pubmed-meshheading:17425742-Graft Survival,
pubmed-meshheading:17425742-Humans,
pubmed-meshheading:17425742-Ileostomy,
pubmed-meshheading:17425742-Immunosuppressive Agents,
pubmed-meshheading:17425742-Intestine, Small,
pubmed-meshheading:17425742-Male,
pubmed-meshheading:17425742-Middle Aged,
pubmed-meshheading:17425742-Radiation Injuries,
pubmed-meshheading:17425742-Reconstructive Surgical Procedures,
pubmed-meshheading:17425742-Short Bowel Syndrome,
pubmed-meshheading:17425742-Surgical Mesh
|
| pubmed:articleTitle |
Twenty-five consecutive isolated intestinal transplants in adult patients: a five-yr clinical experience.
|
| pubmed:affiliation |
Liver and Multiorgan Transplant Unit, University of Bologna - Policlinico S. Orsola-Malpighi, Bologna, Italy. augustola@yahoo.it
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| pubmed:publicationType |
Journal Article
|