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rdf:type |
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lifeskim:mentions |
umls-concept:C0003467,
umls-concept:C0034693,
umls-concept:C0205263,
umls-concept:C0599883,
umls-concept:C0871261,
umls-concept:C0871388,
umls-concept:C1522496,
umls-concept:C1548147,
umls-concept:C1704632,
umls-concept:C1704650,
umls-concept:C1706817,
umls-concept:C2828358,
umls-concept:C2911692
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pubmed:issue |
5
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pubmed:dateCreated |
2007-4-11
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pubmed:abstractText |
Hypothalamo-pituitary-adrenal axis responses to various stressors are typically attenuated during lactation, including in rats selectively bred for high or low anxiety. As high-anxiety dams are more aggressive towards intruders than low-anxiety dams during maternal defence, we investigated their hypothalamo-pituitary-adrenal axis responses to this social stress. Maternal defence induced elevated stress responses in high-anxiety dams only; nerve-growth-factor-induced gene B mRNA expression in the parvocellular paraventricular nucleus and adrenocorticotropin hormone secretory responses were substantially enhanced after maternal defence. In contrast, secretory responses to a non-social stress (elevated platform) were not different between high- and low-anxiety dams. Thus, responsiveness of the stress axis in lactation is dependent upon the innate level of anxiety of the dam and, as a consequence, her reactiveness to social threat.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adrenocorticotropic Hormone,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Lactic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Nr4a1 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Receptor Subfamily 4...,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cytoplasmic and Nuclear,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Steroid,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0953-816X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
25
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1599-603
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:17425585-Adrenocorticotropic Hormone,
pubmed-meshheading:17425585-Analysis of Variance,
pubmed-meshheading:17425585-Animals,
pubmed-meshheading:17425585-Anxiety,
pubmed-meshheading:17425585-Behavior, Animal,
pubmed-meshheading:17425585-DNA-Binding Proteins,
pubmed-meshheading:17425585-Exploratory Behavior,
pubmed-meshheading:17425585-Female,
pubmed-meshheading:17425585-Hypothalamo-Hypophyseal System,
pubmed-meshheading:17425585-Lactic Acid,
pubmed-meshheading:17425585-Male,
pubmed-meshheading:17425585-Maternal Behavior,
pubmed-meshheading:17425585-Maze Learning,
pubmed-meshheading:17425585-Nuclear Receptor Subfamily 4, Group A, Member 1,
pubmed-meshheading:17425585-Pituitary-Adrenal System,
pubmed-meshheading:17425585-Pregnancy,
pubmed-meshheading:17425585-Rats,
pubmed-meshheading:17425585-Receptors, Cytoplasmic and Nuclear,
pubmed-meshheading:17425585-Receptors, Steroid,
pubmed-meshheading:17425585-Stress, Psychological,
pubmed-meshheading:17425585-Transcription Factors
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pubmed:year |
2007
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pubmed:articleTitle |
Social stress induces hypothalamo-pituitary-adrenal axis responses in lactating rats bred for high trait anxiety.
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pubmed:affiliation |
Centre for Integrative Physiology, College of Medicine and Veterinary Medicine, The University of Edinburgh, Edinburgh, EH8 9XD, UK. alison.j.douglas@ed.ac.uk
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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