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PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
2008-7-21
pubmed:abstractText
The loss of presynaptic markers is thought to represent a strong pathologic correlate of cognitive decline in Alzheimer's disease (AD). Spinophilin is a postsynaptic marker mainly located to the heads of dendritic spines. We assessed total numbers of spinophilin-immunoreactive puncta in the CA1 and CA3 fields of hippocampus and area 9 in 18 elderly individuals with various degrees of cognitive decline. The decrease in spinophilin-immunoreactivity was significantly related to both Braak neurofibrillary tangle (NFT) staging and clinical severity but not A beta deposition staging. The total number of spinophilin-immunoreactive puncta in CA1 field and area 9 were significantly related to MMSE scores and predicted 23.5 and 61.9% of its variability. The relationship between total number of spinophilin-immunoreactive puncta in CA1 field and MMSE scores did not persist when adjusting for Braak NFT staging. In contrast, the total number of spinophilin-immunoreactive puncta in area 9 was still significantly related to the cognitive outcome explaining an extra 9.6% of MMSE and 25.6% of the Clinical Dementia Rating scores variability. Our data suggest that neocortical dendritic spine loss is an independent parameter to consider in AD clinicopathologic correlations.
pubmed:grant
pubmed:commentsCorrections
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http://linkedlifedata.com/resource/pubmed/commentcorrection/17420070-1202204, http://linkedlifedata.com/resource/pubmed/commentcorrection/17420070-12025941, http://linkedlifedata.com/resource/pubmed/commentcorrection/17420070-12044473, http://linkedlifedata.com/resource/pubmed/commentcorrection/17420070-12086707, http://linkedlifedata.com/resource/pubmed/commentcorrection/17420070-12176077, http://linkedlifedata.com/resource/pubmed/commentcorrection/17420070-12360324, http://linkedlifedata.com/resource/pubmed/commentcorrection/17420070-12399581, http://linkedlifedata.com/resource/pubmed/commentcorrection/17420070-12432762, http://linkedlifedata.com/resource/pubmed/commentcorrection/17420070-12528818, http://linkedlifedata.com/resource/pubmed/commentcorrection/17420070-12595205, http://linkedlifedata.com/resource/pubmed/commentcorrection/17420070-12617964, http://linkedlifedata.com/resource/pubmed/commentcorrection/17420070-12743238, http://linkedlifedata.com/resource/pubmed/commentcorrection/17420070-12820162, http://linkedlifedata.com/resource/pubmed/commentcorrection/17420070-12975814, http://linkedlifedata.com/resource/pubmed/commentcorrection/17420070-1373017, http://linkedlifedata.com/resource/pubmed/commentcorrection/17420070-14119171, http://linkedlifedata.com/resource/pubmed/commentcorrection/17420070-14643375, http://linkedlifedata.com/resource/pubmed/commentcorrection/17420070-14704219, http://linkedlifedata.com/resource/pubmed/commentcorrection/17420070-15217898, http://linkedlifedata.com/resource/pubmed/commentcorrection/17420070-15465982, http://linkedlifedata.com/resource/pubmed/commentcorrection/17420070-15514983, http://linkedlifedata.com/resource/pubmed/commentcorrection/17420070-15652981, http://linkedlifedata.com/resource/pubmed/commentcorrection/17420070-15972962, http://linkedlifedata.com/resource/pubmed/commentcorrection/17420070-16079410, http://linkedlifedata.com/resource/pubmed/commentcorrection/17420070-16289476, http://linkedlifedata.com/resource/pubmed/commentcorrection/17420070-16399212, http://linkedlifedata.com/resource/pubmed/commentcorrection/17420070-16510735, http://linkedlifedata.com/resource/pubmed/commentcorrection/17420070-16651885, http://linkedlifedata.com/resource/pubmed/commentcorrection/17420070-1706358, http://linkedlifedata.com/resource/pubmed/commentcorrection/17420070-1759558, http://linkedlifedata.com/resource/pubmed/commentcorrection/17420070-1789684, http://linkedlifedata.com/resource/pubmed/commentcorrection/17420070-1793176, http://linkedlifedata.com/resource/pubmed/commentcorrection/17420070-1899001, http://linkedlifedata.com/resource/pubmed/commentcorrection/17420070-1903014, http://linkedlifedata.com/resource/pubmed/commentcorrection/17420070-2110534, http://linkedlifedata.com/resource/pubmed/commentcorrection/17420070-2127598, http://linkedlifedata.com/resource/pubmed/commentcorrection/17420070-2360787, http://linkedlifedata.com/resource/pubmed/commentcorrection/17420070-2456021, http://linkedlifedata.com/resource/pubmed/commentcorrection/17420070-2472039, http://linkedlifedata.com/resource/pubmed/commentcorrection/17420070-2496154, http://linkedlifedata.com/resource/pubmed/commentcorrection/17420070-2505201, http://linkedlifedata.com/resource/pubmed/commentcorrection/17420070-2927643, http://linkedlifedata.com/resource/pubmed/commentcorrection/17420070-3059748, http://linkedlifedata.com/resource/pubmed/commentcorrection/17420070-3113670, http://linkedlifedata.com/resource/pubmed/commentcorrection/17420070-3572454, http://linkedlifedata.com/resource/pubmed/commentcorrection/17420070-4078621, http://linkedlifedata.com/resource/pubmed/commentcorrection/17420070-7283403, http://linkedlifedata.com/resource/pubmed/commentcorrection/17420070-7566338, http://linkedlifedata.com/resource/pubmed/commentcorrection/17420070-7566340, http://linkedlifedata.com/resource/pubmed/commentcorrection/17420070-7700527, http://linkedlifedata.com/resource/pubmed/commentcorrection/17420070-7721988, http://linkedlifedata.com/resource/pubmed/commentcorrection/17420070-7791901, http://linkedlifedata.com/resource/pubmed/commentcorrection/17420070-7809099, http://linkedlifedata.com/resource/pubmed/commentcorrection/17420070-8232972, http://linkedlifedata.com/resource/pubmed/commentcorrection/17420070-8269086, http://linkedlifedata.com/resource/pubmed/commentcorrection/17420070-8363352, http://linkedlifedata.com/resource/pubmed/commentcorrection/17420070-8434881, http://linkedlifedata.com/resource/pubmed/commentcorrection/17420070-8557847, http://linkedlifedata.com/resource/pubmed/commentcorrection/17420070-8614831, http://linkedlifedata.com/resource/pubmed/commentcorrection/17420070-8793734, http://linkedlifedata.com/resource/pubmed/commentcorrection/17420070-8794079, http://linkedlifedata.com/resource/pubmed/commentcorrection/17420070-8797153, http://linkedlifedata.com/resource/pubmed/commentcorrection/17420070-9023726, http://linkedlifedata.com/resource/pubmed/commentcorrection/17420070-9258263, http://linkedlifedata.com/resource/pubmed/commentcorrection/17420070-9259492, http://linkedlifedata.com/resource/pubmed/commentcorrection/17420070-9275233, http://linkedlifedata.com/resource/pubmed/commentcorrection/17420070-9452470, http://linkedlifedata.com/resource/pubmed/commentcorrection/17420070-9629521
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
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