Linked Life Data

17420058

Source:http://linkedlifedata.com/resource/pubmed/id/17420058

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2007-5-29
pubmed:abstractText
Establishment of polarity is an essential process during proliferation, migration and differentiation in neurons, and the signaling pathways leading to polarization of the cytoskeleton are topics of intense research. One key marker for cell polarity is the centrosome, also known as the microtubule-organizing center. Recent discoveries have shown that the position of the centrosome is precisely regulated during neurogenesis, migration and differentiation, leading to the segregation of cell fate factors, efficient nucleokinesis and directed neurite outgrowth, respectively. Here, we review recent advances in the understanding of this interesting organelle and propose a model whereby centrosome position, determined by extracellular factors, directs multiple aspects of neuronal development.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0166-2236
pubmed:author
pubmed:issnType
Print
pubmed:volume
30
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
276-83
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
The centrosome in neuronal development.
pubmed:affiliation
Biomedical Sciences Graduate Program, Department of Neurosciences, University of California, LBR 3A16, 9500 Gilman Drive, La Jolla, CA 92093, USA.
pubmed:publicationType
Journal Article, Review