The synthesis of a series of aminoethylbiphenyls as novel 5-HT(7) receptor ligands is described. The novel derivatives exhibit high affinity for the 5-HT(7) receptor with selectivity toward 5-HT(1A) receptor.
Centre d'Etudes et de Recherche sur le Médicament de Normandie EA3915, Université de Caen, UFR des Sciences Pharmaceutiques, 5, rue Vaubénard 14032 Caen Cedex, France.