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rdf:type |
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lifeskim:mentions |
umls-concept:C0016030,
umls-concept:C0017262,
umls-concept:C0086418,
umls-concept:C0185117,
umls-concept:C0331858,
umls-concept:C0392756,
umls-concept:C0600437,
umls-concept:C1123023,
umls-concept:C1704640,
umls-concept:C1706515,
umls-concept:C2911684
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pubmed:issue |
1
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pubmed:dateCreated |
2007-5-7
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pubmed:abstractText |
Chronic, nonhealing skin wounds are a common ailment in uncontrolled diabetes and are associated with significant morbidity. The nonhealing diabetic foot wound displays pathologically elevated matrix metalloproteinase (MMP) activity. In contrast, the concentration of nitric oxide (NO) is significantly reduced in these chronic ulcers. Addition of NO to diabetic wounds improves wound healing, but the mechanism for this effect is poorly understood.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0022-4804
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
140
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
90-8
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pubmed:meshHeading |
pubmed-meshheading:17418871-Cell Division,
pubmed-meshheading:17418871-Cells, Cultured,
pubmed-meshheading:17418871-Diabetes Complications,
pubmed-meshheading:17418871-Female,
pubmed-meshheading:17418871-Fibroblasts,
pubmed-meshheading:17418871-Gene Expression Regulation, Enzymologic,
pubmed-meshheading:17418871-Humans,
pubmed-meshheading:17418871-Male,
pubmed-meshheading:17418871-Matrix Metalloproteinase 8,
pubmed-meshheading:17418871-Matrix Metalloproteinase 9,
pubmed-meshheading:17418871-Nitric Oxide,
pubmed-meshheading:17418871-Nitric Oxide Donors,
pubmed-meshheading:17418871-Nitro Compounds,
pubmed-meshheading:17418871-S-Nitroso-N-Acetylpenicillamine,
pubmed-meshheading:17418871-S-Nitrosoglutathione,
pubmed-meshheading:17418871-Skin,
pubmed-meshheading:17418871-Skin Ulcer,
pubmed-meshheading:17418871-Time Factors,
pubmed-meshheading:17418871-Wound Healing
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pubmed:year |
2007
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pubmed:articleTitle |
Nitric oxide donors selectively reduce the expression of matrix metalloproteinases-8 and -9 by human diabetic skin fibroblasts.
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pubmed:affiliation |
Department of Orthopaedics, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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