Source:http://linkedlifedata.com/resource/pubmed/id/17418407
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
2007-4-9
|
| pubmed:abstractText |
The application of novel genetic/genomic technologies to the study of acute leukemia has frequently been a proving ground for such approaches in cancer. Recent development of high-resolution single-nucleotide polymorphism (SNP) arrays allows detailed assessment of the genomes in cancer cells. A recent study by Mullighan et al. uses SNP arrays to assess copy number alterations in a large group of childhood acute lymphoblastic leukemias and demonstrates frequent mutation of genes encoding transcription factors important for B cell development. These studies not only provide information about the multistep development of leukemia, but also demonstrate the potential for this approach in other cancers.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Apr
|
| pubmed:issn |
1535-6108
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
11
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
308-9
|
| pubmed:meshHeading |
pubmed-meshheading:17418407-Chromosome Aberrations,
pubmed-meshheading:17418407-Genome, Human,
pubmed-meshheading:17418407-Humans,
pubmed-meshheading:17418407-Leukemia,
pubmed-meshheading:17418407-Loss of Heterozygosity,
pubmed-meshheading:17418407-Microsatellite Repeats,
pubmed-meshheading:17418407-Polymorphism, Single Nucleotide
|
| pubmed:year |
2007
|
| pubmed:articleTitle |
Genome-wide SNP analysis in cancer: leukemia shows the way.
|
| pubmed:affiliation |
Division of Hematology/Oncology, Children's Hospital and Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.
|
| pubmed:publicationType |
Journal Article,
Review
|