Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2007-4-30
pubmed:abstractText
Glycosylation defects occur in several human diseases. In IgA nephropathy, IgA1 contains O-glycans that are galactose-deficient and consist mostly of core 1 alpha2,6 sialylated N-acetylgalactosamine, a configuration suspected to prevent beta1,3 galactosylation. We confirmed the same aberrancy in IgA1 secreted by the human DAKIKI B cell line. Biochemical assays indicated CMP-NeuAc:GalNAc-IgA1 alpha2,6-sialyltransferase activity in this cell line. However, a candidate enzyme, ST6-GalNAcI, was not transcribed in DAKIKI cells, B cells isolated from blood, or Epstein-Barr virus (EBV)-immortalized IgA1-producing cells from the blood of IgAN patients and healthy controls. Instead, ST6-GalNAcII transcription was detected at a high level. Expression of the ST6-GalNAcII gene and activity of the CMP-NeuAc:GalNAc-IgA1 alpha2,6-sialyltransferase were higher in IgA1-producing cell lines from IgAN patients than in such cells from healthy controls. These data are the first evidence that human cells that lack ST6-GalNAcI can sialylate core 1 GalNAc-Ser/Thr.
pubmed:grant
http://linkedlifedata.com/resource/pubmed/grant/DE13694, http://linkedlifedata.com/resource/pubmed/grant/DK078244, http://linkedlifedata.com/resource/pubmed/grant/DK47322, http://linkedlifedata.com/resource/pubmed/grant/DK61525, http://linkedlifedata.com/resource/pubmed/grant/DK64400, http://linkedlifedata.com/resource/pubmed/grant/DK71802, http://linkedlifedata.com/resource/pubmed/grant/M01 RR000032-46, http://linkedlifedata.com/resource/pubmed/grant/M01 RR000211-41, http://linkedlifedata.com/resource/pubmed/grant/M01 RR00032, http://linkedlifedata.com/resource/pubmed/grant/M01 RR00211, http://linkedlifedata.com/resource/pubmed/grant/P01 DK061525-019001, http://linkedlifedata.com/resource/pubmed/grant/R01 DE013694-05, http://linkedlifedata.com/resource/pubmed/grant/R01 DK071802-01A1, http://linkedlifedata.com/resource/pubmed/grant/R01 DK078244-01, http://linkedlifedata.com/resource/pubmed/grant/R24 DK064400-019002
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/17418236-10232333, http://linkedlifedata.com/resource/pubmed/commentcorrection/17418236-10393701, http://linkedlifedata.com/resource/pubmed/commentcorrection/17418236-10536037, http://linkedlifedata.com/resource/pubmed/commentcorrection/17418236-10607764, http://linkedlifedata.com/resource/pubmed/commentcorrection/17418236-10736101, http://linkedlifedata.com/resource/pubmed/commentcorrection/17418236-10872809, http://linkedlifedata.com/resource/pubmed/commentcorrection/17418236-11095664, http://linkedlifedata.com/resource/pubmed/commentcorrection/17418236-11231363, http://linkedlifedata.com/resource/pubmed/commentcorrection/17418236-11274229, http://linkedlifedata.com/resource/pubmed/commentcorrection/17418236-11399322, http://linkedlifedata.com/resource/pubmed/commentcorrection/17418236-11532091, http://linkedlifedata.com/resource/pubmed/commentcorrection/17418236-11677243, http://linkedlifedata.com/resource/pubmed/commentcorrection/17418236-11720004, http://linkedlifedata.com/resource/pubmed/commentcorrection/17418236-12110007, http://linkedlifedata.com/resource/pubmed/commentcorrection/17418236-12133959, http://linkedlifedata.com/resource/pubmed/commentcorrection/17418236-12361956, http://linkedlifedata.com/resource/pubmed/commentcorrection/17418236-12438318, http://linkedlifedata.com/resource/pubmed/commentcorrection/17418236-12464682, http://linkedlifedata.com/resource/pubmed/commentcorrection/17418236-12754287, http://linkedlifedata.com/resource/pubmed/commentcorrection/17418236-15086888, http://linkedlifedata.com/resource/pubmed/commentcorrection/17418236-15337464, http://linkedlifedata.com/resource/pubmed/commentcorrection/17418236-15466199, http://linkedlifedata.com/resource/pubmed/commentcorrection/17418236-15661235, http://linkedlifedata.com/resource/pubmed/commentcorrection/17418236-15673298, http://linkedlifedata.com/resource/pubmed/commentcorrection/17418236-15728186, http://linkedlifedata.com/resource/pubmed/commentcorrection/17418236-15750391, http://linkedlifedata.com/resource/pubmed/commentcorrection/17418236-16251947, http://linkedlifedata.com/resource/pubmed/commentcorrection/17418236-16510764, http://linkedlifedata.com/resource/pubmed/commentcorrection/17418236-17275907, http://linkedlifedata.com/resource/pubmed/commentcorrection/17418236-2140570, http://linkedlifedata.com/resource/pubmed/commentcorrection/17418236-2628063, http://linkedlifedata.com/resource/pubmed/commentcorrection/17418236-2681181, http://linkedlifedata.com/resource/pubmed/commentcorrection/17418236-3093850, http://linkedlifedata.com/resource/pubmed/commentcorrection/17418236-3337116, http://linkedlifedata.com/resource/pubmed/commentcorrection/17418236-3911017, http://linkedlifedata.com/resource/pubmed/commentcorrection/17418236-4328696, http://linkedlifedata.com/resource/pubmed/commentcorrection/17418236-4373463, http://linkedlifedata.com/resource/pubmed/commentcorrection/17418236-4509329, http://linkedlifedata.com/resource/pubmed/commentcorrection/17418236-6092467, http://linkedlifedata.com/resource/pubmed/commentcorrection/17418236-6247394, http://linkedlifedata.com/resource/pubmed/commentcorrection/17418236-6417260, http://linkedlifedata.com/resource/pubmed/commentcorrection/17418236-6619128, http://linkedlifedata.com/resource/pubmed/commentcorrection/17418236-7758349, http://linkedlifedata.com/resource/pubmed/commentcorrection/17418236-7774058, http://linkedlifedata.com/resource/pubmed/commentcorrection/17418236-8253749, http://linkedlifedata.com/resource/pubmed/commentcorrection/17418236-8325028, http://linkedlifedata.com/resource/pubmed/commentcorrection/17418236-9140997, http://linkedlifedata.com/resource/pubmed/commentcorrection/17418236-9264010, http://linkedlifedata.com/resource/pubmed/commentcorrection/17418236-9442070, http://linkedlifedata.com/resource/pubmed/commentcorrection/17418236-9568852
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0022-2836
pubmed:author
More...